Amylin:new insight into pathogenesis,diagnosis,and prognosis of non-insulin-dependent diabetesmellitus-related cardiomyopathy  

作　　者：Jiaying Xie Zhoujie Tong Longfei Shen Yuanyuan Shang Yulin Li Bin Lu Weixuan Ma Wei Zhang Ming Zhong 

机构地区：[1]The Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education,Chinese National Health Commission and Chinese Academy of Medical Sciences,The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine,Department of Cardiology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan,Shandong,China

出　　处：《Emergency and Critical Care Medicine》2022年第1期32-38,共7页急危重症医学（英文）

基　　金：This work was supported by research grants from the National Natural Science Foundation of China(82070392 and 81900332).

摘　　要：Co-secretion with insulin,highly amyloidogenic human amylin is considered to contribute to the initiation and progression of diabetic heart complications,despite other situations such as hypertension and atherosclerosis.In response to insulin resistance,hyperinsulinemia,and consequently hyperamylinemia,is common in prediabetic patients,where highly concentrated amylin is prone to form amylin oligomers,which further assemble into fibrils and amyloids with high b-sheet content.The infusion and deposition of oligomeric amylin in myocytes cause a series of consequences,including cytosolic Ca^(2+)dysregulation,calmodulin activation,myocyte hypertrophy,and ventricular stiffness,eventually leading to heart failure.In this review,we present the latest reports of amylin-related heart complications,provide new insights,and state the underlying pathogenesis,diagnosis,possible treatment,and prevention of diabetic cardiomyopathy.

关 键 词：AMYLIN AMYLOID Diabetic cardiomyopathy a-helix b-sheet 

分 类 号：R54[医药卫生—心血管疾病]