云南高校图书馆联盟文献共享服务平台- AMYLIN

AMYLIN: 作品数：53被引量：13H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王宜冰李艳梅杜晨光周晋萌许霖水更多>>; 相关机构：内蒙古农业大学成都贝爱特生物科技有限公司教育部华东理工大学更多>>; 相关期刊：《中国药学杂志》《生命的化学》《Science China(Life Sciences)》《药学进展》更多>>; 相关基金：国家自然科学基金国家教育部博士点基金上海市青年科技启明星计划山东省自然科学基金更多>>

Amylin通过蓝斑核(LC)调节采食: 《中国兽医学报》2024年第12期2605-2611,共7页樊奇刘昊东李鹏辉李嘉成王星杜晨光; 国家自然科学基金资助项目(32060204);内蒙古科技攻关计划资助项目(2021GG0199,2022YFHH0015);内蒙古自治区直属高校基本科研业务费资助项目(BR231507);内蒙古自治区教育厅高等学校科学研究资助项目(NJZY22535,NJZY23120);学院草食家畜优异种质资源科技创新团队资助项目(TDY202302)。; 胰淀素(amylin)通过影响中枢核团对能量代谢平衡的控制,发挥限制进食量的饱腹作用。然而,amylin在中枢神经系统中的结合位点分布较广,蓝斑核(locus coeruleus,LC)是否响应amylin的刺激作用尚不清楚。因此,本试验欲通过局部LC核团损伤,...; 关键词：胰淀素蓝斑核酪氨酸羟化酶产热小鼠

A pancreatic player in dementia:pathological role for islet amyloid polypeptide accumulation in the brain: 《Neural Regeneration Research》2023年第10期2141-2146,共6页Angelina S.Bortoletto Ronald J.Parchem; supported by The Mike Hogg Fund;Baylor College of Medicine Medical Scientist Training Program,NICHD R01HD099252(to RJP)and R01HD098131(to RJP);the NHLBI T32 HL092332(to ASB)。; Type 2 diabetes mellitus patients have a markedly higher risk of developing dementia.While multiple factors contribute to this predisposition,one of these involves the increased secretion of amylin,or islet amyloid po...; 关键词：Alzheimer’s disease AMYLIN AMYLOID DEMENTIA diabetes human islet amyloid polypeptide islet amyloid polypeptide PROTOFIBRILS type 2 diabetes mellitus vascular dementia

Amylin和Preptin与多囊卵巢综合征的相关性研究: 《中国优生与遗传杂志》2023年第2期295-300,共6页宋友兰吴兴国杨默吴寒刘梦晨张文娟; 山东省自然科学基金(ZR2016HL04);山东省学校卫生协会科研课题(SDWS2022115);泰安市科技创新发展项目(2020NS266)。; 目的比较PCOS患者与对照组的Amylin和Preptin水平,探讨其与多囊卵巢综合征(PCOS)的相关性,为PCOS的早期诊断和防治提供新的策略和实验依据。方法选取PCOS患者和同期就诊的非PCOS对照组各40名作为研究对象。所有研究对象测定性腺激素六...; 关键词：多囊卵巢综合征 AMYLIN PREPTIN 胰岛素抵抗

3种饮食诱导的非酒精性脂肪性肝炎小鼠模型表型比较: 《中国临床医学》2022年第4期669-673,共5页孟庆楠张晓芙熊雪莲; 国家自然科学基金面上项目(81970740);上海市科委青年科技启明星计划(20QA1402000I)。; 目的比较3种饮食诱导的非酒精性脂肪性肝炎(NASH)小鼠模型的特征,从而为NASH的机制研究和药物研发提供参考。方法分别用高脂饮食(HFD)喂养24周、Amylin饮食喂养24周、高脂-蛋氨酸胆碱缺乏饮食(HFMCD)喂养10周,诱导小鼠NASH表型,并用正...; 关键词：非酒精性脂肪性肝炎高脂饮食 Amylin饮食高脂-蛋氨酸胆碱缺乏饮食动物模型

Amylin:new insight into pathogenesis,diagnosis,and prognosis of non-insulin-dependent diabetesmellitus-related cardiomyopathy: 《Emergency and Critical Care Medicine》2022年第1期32-38,共7页Jiaying Xie Zhoujie Tong Longfei Shen Yuanyuan Shang Yulin Li Bin Lu Weixuan Ma Wei Zhang Ming Zhong; This work was supported by research grants from the National Natural Science Foundation of China(82070392 and 81900332).; Co-secretion with insulin,highly amyloidogenic human amylin is considered to contribute to the initiation and progression of diabetic heart complications,despite other situations such as hypertension and atheroscleros...; 关键词：AMYLIN AMYLOID Diabetic cardiomyopathy a-helix b-sheet

Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics被引量：1: 《Acta Pharmaceutica Sinica B》2022年第2期621-636,共16页Carlos Bendicho-Lavilla Iria Seoane-Viano Francisco J.OteroEspinar Asteria Luzardo-Alvarez; funded by Xunta de Galicia grant number GRC2013/015 and GPC2017/015(Spain)。; Diabetes mellitus is a major health problem with increasing prevalence at a global level.The discovery of insulin in the early 1900 s represented a major breakthrough in diabetes management,with further milestones bei...; 关键词：Type 2 diabetes mellitus Glucagon-like peptide-1 receptor agonists EXENATIDE Subcutaneous administration Amylin mimetics Drug delivery systems BIOTHERAPEUTICS Peptide delivery Controlled-release formulations Microparticles Nanoparticles

Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease:two triggers, one disease被引量：5: 《Neural Regeneration Research》2021年第6期1127-1130,共4页Sofia Ferreira Ana F.Raimundo Regina Menezes Ivo C.Martins; supported by iNOVA4Health-UID/Multi/04462/2019,a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência,through national funds and co-funded by FEDER under the PT2020 Partnership Agreement,Funding from INTERFACE Programme,through the Innovation,Technology and Circular Economy Fund(FITEC),FCT via PTDC/BIA-MOL/31104/2017 and UID/Multi/04462/2019-SubProj iNOVA4Health C44(to RM),PD/BD/135504/2018(to AFR);Sociedade Portuguesa de Diabetologia for the Nuno Castelo-Branco Prize-2016(to RM),and ICM acknowledges FCT-MCTES Program“Concurso de Estímulo ao Emprego Científico”(CEECIND/01670/2017).; Alzheimer’s disease(AD)is a neurodegenerative disorder that affects millions worldwide.Due to population ageing,the incidence of AD is increasing.AD patients develop cognitive decline and dementia,features for which ...; 关键词：aggregation ALZHEIMER AMYLIN AMYLOID diabetes islet amyloid polypeptide

Mechanism of human amylin upregulation intracellular calcium on rat primary cultured hippocampus neurons: 《中国药理学与毒理学杂志》2018年第9期686-686,共1页MA Huan-huan YANG Zu-xiao QIN Xia FU Xue-rui ZHANG Wei; Alzheimer disease(AD) and typeⅡdiabetes mellitus(DM2) are the most common disease in aging people,with β-amyloid and amylin accumulation respectively.Studies have shown more and more correlations between these two d...; 关键词：HUMAN AMYLIN calcium HIPPOCAMPUS NEURONS transient receptor potential VANILLOID

胰淀素调控生理机能的研究进展: 《中国畜牧杂志》2018年第4期20-23,共4页郭志凯范奎奎潘登李强钱英红杜晨光; 国家自然科学基金(31660701;31160455); 胰淀素(Amylin)在机体能量代谢平衡过程中具有重要作用,通过兴奋机体饱食中枢来抑制动物摄食,Amylin的受体广泛分布于第四脑室底部最后区(AP),当受体被激活后,神经信号会通过孤束核(NTS)传至前脑,同时还可通过外侧旁核(LPBN)传至下丘脑...; 关键词：AMYLIN 能量代谢最后区下丘脑

Homology modeling and structural validation of human amylin: A type 2 diabetes causing protein: 《Journal of Coastal Life Medicine》2017年第6期270-274,共5页Gousia Shaik Janakiram Bobbilipati Naveena Lavanya Latha Jeevigunta; Objective:In the present study, the protein structure model of human amylin was generated to understand the protein's structure, function and mechanism of the action. Methods: The stereo chemical quality of the protei...; 关键词：HUMAN AMYLIN SOPMA BLAST PROCHECK SWISS MODEL

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