PROTOFIBRILS

作品数：2被引量：0H指数：0
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相关领域：医药卫生更多>>
相关期刊：《Chinese Journal of Chemical Engineering》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金更多>>
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A pancreatic player in dementia:pathological role for islet amyloid polypeptide accumulation in the brain
《Neural Regeneration Research》2023年第10期2141-2146,共6页Angelina S.Bortoletto Ronald J.Parchem 
supported by The Mike Hogg Fund;Baylor College of Medicine Medical Scientist Training Program,NICHD R01HD099252(to RJP)and R01HD098131(to RJP);the NHLBI T32 HL092332(to ASB)。
Type 2 diabetes mellitus patients have a markedly higher risk of developing dementia.While multiple factors contribute to this predisposition,one of these involves the increased secretion of amylin,or islet amyloid po...
关键词：Alzheimer’s disease AMYLIN AMYLOID DEMENTIA diabetes human islet amyloid polypeptide islet amyloid polypeptide PROTOFIBRILS type 2 diabetes mellitus vascular dementia 
Molecular basis of cross-interactions between Aβ and Tau protofibrils probed by molecular simulations
《Chinese Journal of Chemical Engineering》2023年第3期173-180,共8页Fufeng Liu Luying Jiang Jingcheng Sang Fuping Lu Li Li 
funded by the National Natural Science Foundation of China (21908165 and 21878234);Regional Innovation System Project (21ZYQCSY00050)。
Amyloid β-protein(Aβ) and Tau, two common pathogenic proteins associated with Alzheimer’s disease(AD), cross-interact, and thus co-assemble into hybrid aggregates. However, molecular mechanism of the cross-interact...
关键词：Alzheimer’s disease Amyloidβ-protein Tau Cross-interactions Protein-protein docking Molecular dynamics simulation 
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