EXENATIDE

作品数：93被引量：165H指数：8
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The anti-inflammatory feature of glucagon-like peptide-1 and its based diabetes drugs-Therapeutic potential exploration in lung injury被引量：2
《Acta Pharmaceutica Sinica B》2022年第11期4040-4055,共16页Juan Pang Jia Nuo Feng Wenhua Ling Tianru Jin 
supported by the Canadian Institutes of Health Research (PJT159735 to Tianru Jin, Canada);supported by China Scholarship Council;supported by Ontario Graduate Scholarship (OGS) Program and the Banting & Best Diabetes Centre (BBDC)-Novo Nordisk Studentship
Since 2005,GLP-1 receptor(GLP-IR)agonists(GLP-IRAs)have been developed as therapeutic agents for type 2 diabetes(T2D).GLP-IR is not only expressed in pancreatic islets but also other organs,especially the lung.However...
关键词：Anti inflammation EXENATIDE GLP-1R GLP-1RAs LIRAGLUTIDE Lung injury MSC-based therapy TxNIP 
Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing被引量：8
《Neural Regeneration Research》2022年第8期1652-1658,共7页Carmen M.Labandeira Arturo Fraga-Bau David Arias Ron Elena Alvarez-Rodriguez Pablo Vicente-Alba Javier Lago-Garma Ana I.Rodriguez-Perez 
supported by the Spanish Ministry of Health(PI17/00828 and Ciberned);Galician Government(XUGA,ED431C 2018/10,ED431G/05);FEDER(Regional European Development Fund),all to AIRP.
In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,pla...
关键词：ANTIDIABETIC diabetes mellitus dopamine EXENATIDE glucagon-like peptide-1 insulin NEURODEGENERATION NEUROINFLAMMATION Parkinson’s disease repurposing 
Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics被引量：1
《Acta Pharmaceutica Sinica B》2022年第2期621-636,共16页Carlos Bendicho-Lavilla Iria Seoane-Viano Francisco J.OteroEspinar Asteria Luzardo-Alvarez 
funded by Xunta de Galicia grant number GRC2013/015 and GPC2017/015(Spain)。
Diabetes mellitus is a major health problem with increasing prevalence at a global level.The discovery of insulin in the early 1900 s represented a major breakthrough in diabetes management,with further milestones bei...
关键词：Type 2 diabetes mellitus Glucagon-like peptide-1 receptor agonists EXENATIDE Subcutaneous administration Amylin mimetics Drug delivery systems BIOTHERAPEUTICS Peptide delivery Controlled-release formulations Microparticles Nanoparticles 
Short-term combined treatment with exenatide and metformin for overweight/obese women with polycystic ovary syndrome被引量：6
《Chinese Medical Journal》2021年第23期2882-2889,共8页Rui-Lin Ma Yan Deng Yan-Fang Wang Shi-Yang Zhu Xue-Song Ding Ai-Jun Sun 
Background:Obesity and insulin resistance(IR)are common features of polycystic ovary syndrome(PCOS).Metformin(MET)increases insulin sensitivity,but it is associated with unsatisfactory weight loss.The glucagon-like pe...
关键词：Exenatide once-weekly Insulin resistance METFORMIN Obesity Polycystic ovary syndrome 
Comparative Review of Drugs Used in Diabetes Mellitus—New and Old
《Journal of Diabetes Mellitus》2021年第4期115-131,共17页Furqan Ul Haq Abuzar Siraj Muhammad Atif Ameer Tanveer Hamid Mansoor Rahman Salman Khan Saad Khan Sarwat Masud 
Background: Diabetes mellitus (DM) is a syndrome of chronically elevated glucose level in the blood either due to insulin resistance, insulin deficiency or both. In addition, it may occur due to defec...
关键词：Anti-Diabetic Drugs METFORMIN SITAGLIPTIN Canagliflozin EXENATIDE PIOGLITAZONE Insulin Use and Its Efficacy GLIPIZIDE 
Exenatide once weekly combined with metformin reduced glycemic variability in type 2 diabetes by using flash glucose monitoring system
《World Journal of Diabetes》2020年第12期654-665,共12页Yang Li Min-Min Han Qiong He Zi-Ang Liu Dong Liang Jing-Tian Hou Yi Zhang Yun-Feng Liu 
Supported by National Natural Science Foundation of China,No.81770776 and No.81973378;Cultivate Scientific Research Excellence Programs of Higher Education Institutions in Shanxi,No.2019KJ022;Special Project for Transformation and Guidance of Scientific and Technological Achievements in Shanxi Province,No.201804D131044.
BACKGROUND Multiple studies demonstrate that fluctuating blood glucose level produces greater damage compared with sustained hyperglycemia.Flash glucose monitoring system is an effective method in documenting blood gl...
关键词：Flash glucose monitoring Glycemic variability Type 2 diabetes mellitus Exenatide once weekly 
Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS
《Journal of Pharmaceutical Analysis》2020年第3期233-239,共7页Max Sauter Philipp Uhl Jürgen Burhenne Walter E.Haefeli 
funded in part by the German Federal Ministry of Education and Research(BMBF,grant number 03VP03980);supported in part by the Physician Scientist Program of the Faculty of Medicine of Heidelberg University。
Exenatide is the first approved glucagon-like peptide 1 receptor agonist subcutaneously or intramuscularly injected for the treatment of type 2 diabetes mellitus.Typical therapeutic plasma concentrations are in the lo...
关键词：EXENATIDE NASAL INTRAVENOUS UPLC Tandem mass spectrometry PHARMACOKINETICS 
Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release被引量：7
《Asian Journal of Pharmaceutical Sciences》2020年第3期347-355,共9页Ni Dong Chune Zhu Junhuang Jiang Di Huang Xing Li Guilan Quan Yang Liu Wen Tan Xin Pan Chuanbin Wu 
the China Postdoctoral Science Foundation(Grant No.2016M602442);the Science and Technology Plan Projects of Guangdong Province(Grant No.2015B020232010);the 111 project(Grant No.B16047);the Natural Science Fund Project of Guangdong Province(Grant No.2018A030310555,Grant No.2016A030312013)。
This study aimed to prepare poly(D, L-lactic-co-glycolic acid) microspheres(PLGA-Ms)by a modified solid-in-oil-in-water(S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst ...
关键词：MICROSPHERES PLGA PEPTIDES Lipid nanoparticles Sustained drug release 
Exenatide对糖尿病大鼠认知功能的改善作用及机制研究
《海峡药学》2020年第3期20-24,共5页李飞 柯林芳 刘礼斌 陈洲 
福建省自然基金资助(编号:2018J01841)。
目的探讨Exenatide对糖尿病大鼠认知功能的改善作用及机制。方法SD大鼠随机分为正常组、糖尿病组(DM组)及Exenatide给药组(Ex+DM组)。Ex+DM组给药16周,水迷宫检测认知功能;电镜观察海马超微结构;检测与认知相关的p-tau(s202、s396)蛋白...
关键词：EXENATIDE 链脲佐菌素 糖尿病 认知功能 氧化应激 
Comparison of ELISA and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices被引量：1
《Journal of Pharmaceutical Analysis》2019年第3期143-155,共13页A.R. Pinho A. Fortuna A. Falcao A.C. Santos R. Seia C. Estevens F. Veiga A.J. Ribeiro 
The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ing...
关键词：Type 2 diabetes EXENATIDE THERAPEUTIC drug monitoring ELISA HPLC 
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