To the Editor:Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of reproductive age.PCOS is characterized by infrequent or absent ovulation,high androgen levels,and hyperinsulinaemia.Androgenic...
National Key R&D Program of China(2022YFC3500303);National Natural Science Foundation of China(81991522);partly by the Open Project of State Key Laboratory of Natural Medicine,No.SKLNMKF202204,China。
Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor...
BACKGROUND Type A insulin resistance syndrome(TAIRS)is a rare disorder characterized by severe insulin resistance due to defects in insulin receptor signaling.No specific drugs are available for the treatment of TAIRS...
National Natural Science Foundation of China(Grant No.3207040249).
As a pathological result of the abnormal differentiation of adipocytes,the occurrence of obesity will not only lead to weight gain,abnormal energy metabolism,but also the development of the diseases such as diabetes.E...
Background: Diabetes mellitus (DM) is a syndrome of chronically elevated glucose level in the blood either due to insulin resistance, insulin deficiency or both. In addition, it may occur due to defec...
Barbanti FA is supported by a contract financed by Italian Ministry of Health and Italian Regions(NET-2016-02364191).
Despite the fact that non-alcoholic fatty liver disease(NAFLD)and its severe clinical forms[non-alcoholic steatohepatitis(NASH)and NASH-cirrhosis]are highly prevalent in the general population,there are no licensed dr...
This study was financially supported by the Education Commission of Chongqing in China(Grant No.KJQN201800124 to Y.B.Deng and Grant No.CY170402 to C.D.Wang);the Natural Science Foundation of Chongqing China(Grant No.cstc2016jcyjA0220 to X.Jiang and Grant No.cstc2014jcyjA10024 to C.D.Wang);Doctoral Program of Higher Education of China(20125503120015 to C.D.Wang).
Traumatic brain injury(TBI)is the major cause of high mortality and disability rates worldwide.Pioglitazone is an activator of peroxisome proliferator-activated receptor-gamma(PPARγ)that can reduce inflammation follo...
Background:Pioglitazone may be beneficial in the treatment of psoriasis.However,based on the effectiveness and safety considerations,it has not been widely used.To fully evaluate the strength of evidence supporting ps...