FLUTAMIDE

作品数：23被引量：46H指数：4
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相关领域：医药卫生更多>>
相关作者：郑航王小芹郑筠青夏鹏李笑弓更多>>
相关机构：上海医科大学武汉大学重庆医科大学安徽省脑立体定向神经外科研究所更多>>
相关期刊：《中国医药工业杂志》《中国肿瘤临床》《Journal of Animal Science and Biotechnology》《Open Journal of Urology》更多>>
相关基金：国家自然科学基金重庆市自然科学基金安徽省自然科学基金安徽省科技攻关计划更多>>
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Treatment and five-year follow-up of type A insulin resistance syndrome:A case report被引量：1
《World Journal of Clinical Cases》2022年第8期2522-2528,共7页Yong-Hua Chen Qing-Qing Chen Chun-Lin Wang 
BACKGROUND Type A insulin resistance syndrome(TAIRS)is a rare disorder characterized by severe insulin resistance due to defects in insulin receptor signaling.No specific drugs are available for the treatment of TAIRS...
关键词：Type A insulin resistance syndrome TREATMENT PIOGLITAZONE FLUTAMIDE Case report 
Flutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries
《Journal of Animal Science and Biotechnology》2019年第3期618-632,共15页Katarzyna Knapczyk-Stwora Anna Nynca Renata E.Ciereszko Lukasz Paukszto Jan P.Jastrzebski Elzbieta Czaja Patrycja Witek Marek Koziorowski Maria Slomczynska 
supported by grant OPUS9 2015/17/B/NZ9/01457 from the National Science Centre,Poland
Background: Androgens are involved in the regulation of ovarian development during fetal/neonatal life.Environmental chemicals displaying anti-androgenic activities may affect multiple signal transduction pathways by ...
关键词：FLUTAMIDE LncRNA OVARY PIG RNA-Seq TRANSCRIPTOME 
Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease被引量：11
《Neural Regeneration Research》2019年第4期649-657,共9页Xu-Sheng Yan Zhan-Jun Yang Jian-Xin Jia Wei Song Xin Fang Zhi-Ping Cai Dong-Sheng Huo He Wang 
supported by the Natural Science Foundation of Inner Mongolia Autonomous Region of China,No.2017LH0301(to JXJ),2016MS08108(to ZJY);Science and Technology Planning Project of Inner Mongolia Autonomous Region of China,No.201602069(to ZJY);PhD Scientific Research Fund of Baotou Medical College of China,No.BSJJ201606(to JXJ);"Dengfeng Project" Scientific Research Fund of Baotou Medical College of China,No.BYJJ-DF 201703(to JXJ)
Cognitive dysfunction in Alzheimer's disease is strongly associated with a reduction in synaptic plasticity, which may be induced by oxidative stress. Testosterone is beneficial in learning and memory, although the un...
关键词：nerve REGENERATION Alzheimer’s disease TESTOSTERONE cognitive dysfunction synaptic plasticity free radicals MORRIS water maze androgen receptor FLUTAMIDE POSTSYNAPTIC density protein 95 amyloid beta 1–42 NEURODEGENERATIVE change neural REGENERATION 
Prior switching to a second-line nonsteroidal antiandrogen does not impact the therapeutic efficacy of abiraterone acetate in patients with metastatic castration-resistant prostate cancer： a real-world retrospective study被引量：3
《Asian Journal of Andrology》2018年第6期545-550,共6页Jin-G Zhao Jian-Dong Liu Peng-Fei Shen Xin Tang Guang-Xi Sun Xing-Ming Zhang Jun-Ru Chen Kun-Peng Shul Ming Shi Hao Zeng 
This work was supported by the National Natural Science Foundation of China （NSFC 81672547, 81402110, and 81272820）; Science and Technology Support Program of Sichuan Province （2015SZ0142）; and the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University.
Even in the era of novel targeted agents, switching to a second-line nonsteroidal antiandrogen （NSAA） is still widely used in treating metastatic castration-resistant prostate cancer （mCRPC）, especially in undevel...
关键词：ABIRATERONE ANTIANDROGEN castration-resistant prostate cancer FLUTAMIDE 
雄激素受体抑制剂通过AR信号通路对胶质瘤生物学特性的影响被引量：4
《国际神经病学神经外科学杂志》2018年第1期5-9,共5页王长林 牛万祥 程传东 鲍得俊 牛朝诗 
国家自然科学基金项目(编号:81172407);安徽省自然科学基金项目(编号:1408085MKL69);安徽省科技攻关项目(编号:1604a0802069);脑功能与脑疾病安徽省重点实验室绩效考核补助项目(1606c08235)
目的研究雄激素受体(androgen receptor,AR)抑制剂(flutamide)对人胶质瘤细胞增殖、凋亡、侵袭的影响。方法采用不同浓度的flutamide(低浓度1.0×10^(-8)、中浓度1.0×10^(-7)、高浓度1.0×10^(-6)mol/L)作用于胶质瘤细胞系U251,Real Ti...
关键词：胶质瘤 雄激素受体 AR抑制剂(flutamide) 增殖 凋亡 
The effect of flutamide on the physical working capacity and activity of some of the key enzymes for the energy supply in adult rats被引量：2
《Asian Journal of Andrology》2017年第4期444-448,共5页Katerina N Georgieva Penka A Angelova Fani D Gerginska Dora D Terzieva Mihaela S Shishmanova-Doseva Slavi D Delchev Valentine V Vasilev 
The aim of the study was to assess the effects of androgen receptor antagonists on the physical working capacity and activity of some of the key muscle enzymes for the energy supply in rats. Young adult male Wistar ra...
关键词：ANTI-ANDROGEN maximum oxygen consumption maximum time to exhaustion mitochondrial enzymes running economy submaximal running endurance 
Flutamide对前列腺癌细胞分化抑制因子1表达影响
《青岛大学医学院学报》2015年第1期94-96,共3页王德举 郭晓慧 于小玲 
目的了解雄激素受体阻断剂Flutamide对前列腺癌细胞分化抑制因子1（ID1）表达的影响及意义。方法在培养的前列腺癌LNCaP和PC3细胞中分别加入Flutamide,用实时荧光定量反转录聚合酶链式反应（RTPCR）方法检测ID1mRNA相对定量表达;用Weste...
关键词：前列腺肿瘤 LNCAP细胞 PC3细胞 细胞分化抑制因子1 FLUTAMIDE 
Sexual Function in Men with Castrate Levels of Testosterone: Observations of a Subgroup of Sexually Active Men with Prostate Cancer Undergoing Androgen Deprivation Therapy
《Open Journal of Urology》2014年第7期98-103,共6页Evan Ng Tammy Corica Sandra Turner Adeline Lim Nigel Spry 
Purpose: To identify possible factors that influence sexual function in men undergoing maximal androgen deprivation therapy (ADT). Patients and Methods: A descriptive exploration was performed looking at characteristi...
关键词：Prostate Cancer Intermittent ANDROGEN Suppression Exercise Sexual Function LEUPROLIDE FLUTAMIDE 
Testosterone ameliorates streptozotocin-induced memory impairment in male rats
《Acta Pharmacologica Sinica》2014年第6期752-757,共6页Alireza Mohajjel NAYEBI Seyedreza POURRABI Seyedebrahim HOSSINI 
Aim： To study the effects of testosterone on streptozotocin （STZ）-induced memory impairment in male rats. Methods： Adult male Wistar rats were intracerebroventricularly （icv） infused with STZ （750 μg） on d 1 ...
关键词：learning and memory STREPTOZOTOCIN TESTOSTERONE FLUTAMIDE LETROZOLE TAMOXIFEN Alzheimer＇s disease 
Frequent Episodic Vertigo is an Unexpected Side Effect of Flutamide
《Pharmacology & Pharmacy》2011年第4期338-340,共3页Jiann-Jy Chen Dem-Lion Chen 
An 82-year-old male suffered from prostatic cancer five years ago. Since then, he has taken flutamide and was bothered with episodic vertigo (EV) every morning. In order to treat prostatic cancer, flutamide was not di...
关键词：FLUTAMIDE EPISODIC VERTIGO PROSTATIC CANCER 
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