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LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer: 《Cell Research》2025年第1期59-71,共13页Fei Li Pengfei Dai Huili Shi Yajuan Zhang Juan He Anuradha Gopalan Dan Li Yu Chen Yarui Du Guoliang Xu Weiwei Yang Chao Liang Dong Gao; supported by the National Science Fund for Distinguished Young Scholars(32125013);the Excellent Young Scholars Fund(82422052);the National Natural Science Foundation of China(92253304,82002718,92357301,92253305,82461160322);the National Key R&D Program of China(2023YFC2506401);the Jiangsu Natural Science Foundation(BK20191077);the China National Postdoctoral Program for Innovative Talents(BX2021306,BX2024370);the Shanghai Oriental Talent Program,Shanghai Science and Technology Development Funds(22QA1409900,23ZR1470100);Shanghai Municipal Science and Technology Major Project,the Sanofi Scholarship and Heaye Program.; Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression,thereby shaping tumor heterogeneity and therapy response.In ca...; 关键词：LKB1 INACTIVATION PLASTICITY

Computationally guided discovery of novel non-steroidal AR-GR dual antagonists demonstrating potency against antiandrogen resistance被引量：1: 《Acta Pharmacologica Sinica》2023年第7期1500-1518,共19页Xin Chai Xue-ping Hu Xin-yue Wang Hua-ting Wang Jin-ping Pang Wen-fang Zhou Jia-ning Liao Lu-hu Shan Xiao-hong Xu Lei Xu Hong-guang Xia Ting-jun Hou Dan Li; National Key R&D Program of China(2019YFE0111300);National Natural Science Foundation of China(22220102001,22273049);Zhejiang Provincial Natural Science Foundation of China(LD22H300001).; As a major class of medicine for treating the lethal type of castration-resistant prostate cancer(PCa),long-term use of androgen receptor(AR)antagonists commonly leads to antiandrogen resistance.When AR signaling path...; 关键词：prostate cancer androgen receptor glucocorticoid receptor dual antagonists antiandrogen resistance

Role of prostate cancer stem-like cells in the development of antiandrogen resistance被引量：1: 《Cancer Drug Resistance》2022年第2期459-471,共13页Prem Prakash Kushwaha Shiv Verma Shashank Kumar Sanjay Gupta; Androgen deprivation therapy(ADT)is the standard of care treatment for advance stage prostate cancer.Treatment with ADT develops resistance in multiple ways leading to the development of castration-resistant prostate ...; 关键词：Prostate cancer second-generation antiandrogens cancer stem cells castration resistance prostate cancer androgen deprivation therapy

Prior switching to a second-line nonsteroidal antiandrogen does not impact the therapeutic efficacy of abiraterone acetate in patients with metastatic castration-resistant prostate cancer： a real-world retrospective study被引量：3: 《Asian Journal of Andrology》2018年第6期545-550,共6页Jin-G Zhao Jian-Dong Liu Peng-Fei Shen Xin Tang Guang-Xi Sun Xing-Ming Zhang Jun-Ru Chen Kun-Peng Shul Ming Shi Hao Zeng; This work was supported by the National Natural Science Foundation of China （NSFC 81672547, 81402110, and 81272820）; Science and Technology Support Program of Sichuan Province （2015SZ0142）; and the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University.; Even in the era of novel targeted agents, switching to a second-line nonsteroidal antiandrogen （NSAA） is still widely used in treating metastatic castration-resistant prostate cancer （mCRPC）, especially in undevel...; 关键词：ABIRATERONE ANTIANDROGEN castration-resistant prostate cancer FLUTAMIDE

Treatment strategy for metastatic prostate cancer with extremely high PSA level： reconsidering the value of vintage therapy: 《Asian Journal of Andrology》2018年第5期432-437,共6页Yasutaka Yamada Shinichi Sakamoto Yoshiyasu Amiya Makoto Sasaki Takayuki Shima Akira Komiya Noriyuki Suzuki Koichiro Akakura Tomohiko Ichikawae Hiroomi Nakatsu; The prognostic significance of initial prostate-specific antigen （PSA） level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metas...; 关键词：alternative antiandrogen therapy antiandrogen withdrawal hormonal therapy metastatic prostate cancer PROSTATE-SPECIFICANTIGEN

Intermittent, low-dose, antiandrogen monotherapy as an alternative therapeutic option for patients with positive surgical margins after radical prostatectomy被引量：1: 《Asian Journal of Andrology》2018年第3期270-275,共6页Kyung Hwa Choi Seung Ryeol Lee Young Kwon Hong Dong Soo Park; The aim of the present study was to determine whether oncologic outcomes and adverse events associated with active on/off intermittent antiandrogen monotherapy （daily bicalutamide, 50 mg per day） are comparable with...; 关键词：androgen receptor antagonists disease progression margins of excision prostatectomy prostatic neoplasms

Androgen receptor： structure, role in prostate cancer and drug discovery被引量：44: 《Acta Pharmacologica Sinica》2015年第1期3-23,共21页MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG; Androgens and androgen receptors （AR） play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome （AIS） and prostate cancer, are associated with alterations i...; 关键词：ANDROGEN ANDROGEN RECEPTOR PROSTATE cancer nuclear RECEPTOR DRUG discovery rational DRUG design structural biology CASTRATION resistance ANTIANDROGEN

Novel flutamide regulated genes in the rat veritral prostate： differential modulation of their expression by castration and flutamide treatments: 《Asian Journal of Andrology》2007年第6期801-808,共8页Anil M Limaye Irfan Asangani Namrata Bora Paturu Kondaiah; Aim： To identify flutamide regulated genes in the rat ventral prostate. Methods： Total RNA from ventral prostates of control and flutamide treated rats were isolated. Differentially expressed transcripts were identi...; 关键词：ANDROGENS ANTIANDROGEN CASTRATION differential display reverse transcriptase polymerase chain reaction FLUTAMIDE PROSTATE

Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localizect prostate cancer （T1-2）： a retrospective study被引量：1: 《Asian Journal of Andrology》2007年第2期253-258,共6页Rupesh Raina Geetu Pahalajani Ashok Agarwal Craig Zippe; Aim： To evaluate the long-term effectiveness, side effects and compliance rates of two types of drugs （luteinizing hormone-releasing hormone [LHRH] agonist and antiandrogen） that were used individually to treat pat...; 关键词：localized prostate cancer ANTIANDROGEN prostate-specific antigen luteinizing hormone-releasing hormone agonist ANDROGEN ablation MONOTHERAPY

The Antiandrogen Withdrawal Syndrome: 《Journal of Nanjing Medical University》2002年第2期85-85,共1页华立新吴宏飞眭元庚程双管徐正铨张炜钱立新; Objective\ To evaluate the response to antiandrogen withdrawal in patients with advanced prostate cancer treated with combined androgen blockade. Methods\ Twenty four cases of advanced prostate cancer (10 in stage C ...; 关键词：Prostate cancer Prostate specific antigen Antiandrogen withdrawal

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