VANILLOID

作品数：23被引量：42H指数：4
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相关领域：医药卫生更多>>
相关作者：靳凯周辉杨刚王志明代海涛更多>>
相关机构：重庆医科大学附属第一医院石河子大学第三军医大学天津中医药大学更多>>
相关期刊：《World Journal of Diabetes》《Journal of Traditional Chinese Medicine》《Chinese Journal of Integrative Medicine》《Cardiology Discovery》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划重庆市自然科学基金国家临床重点专科建设项目更多>>
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Role and mechanism of Roux-en-Y gastric bypass in the treatment of diabetic urinary bladder hyperactivity by reducing TRPV1 and P2X3
《World Journal of Diabetes》2025年第4期205-219,共15页Guang-Yong Li Shuai Ren Bin-Cheng Huang Jia-Jin Feng Qiang-Qiang Wang Qing-Jie Peng Hai-Fu Tian Le-Yi Yu Cun-Ling Ma Shu-Zhe Fan Xiao-Jiang Chen Mohammed Abdulkarem Al-Qaisi Rui He 
Supported by National Natural Science Foundation of China,No.81860268 and No.82201000;Ningxia Natural Science Foundation,No.2021AAC02025;Ningxia Science and Technology Innovation Leading Talent Training Project;No.2020GKLRLX06 and No.2020GKLRLX11;Ningxia Medical University Research Project,No.XJKF240315;Ningxia Key Research and Development Project,No.2023BEG03021 and No.2021BEB04034.
BACKGROUND Diabetes mellitus(DM)is linked to an earlier onset and heightened severity of urinary complications,particularly bladder dysfunction,which profoundly impacts patient quality of life.Overactive bladder(OAB)i...
关键词：Roux-en-Y gastric bypass Diabetes BLADDER Transient receptor potential vanilloid type 1 P2X3 
Hewei Jiangni granule(和胃降逆颗粒)alleviates visceral hypersensitivity of non-erosive reflux disease via stromal interaction molecule 1/transient receptor potential vanilloid subfamily member 1 pathway
《Journal of Traditional Chinese Medicine》2025年第1期1-12,共12页CHENG Yuan ZHANG Xiaosi LI Junxiang ZHANG Liming DAI Yi XIE Chune SHI Lei LI Xiaohong KOU Fushun 
National Natural Science Foundation of China:Study on the Molecular Mechanism of the Regulation of Crypt Goblet Cell Pyroptosis and Exocytosis to Repair Ulcerative Colitis Mucus Barrier by the Method of Clearing and Opening the Xuanfu from the Perspective of"Xuanfu-Crypt"(No.82305143),and National Natural Science Foundation of China:Exploring the Molecular Mechanism of"Hewei Jiangni Fang"Intervention in Non-erosive Reflux Disease Esophageal Hypersensitivity from the Perspective of Mas-related Gene X2/Stromal Interaction Molecule 1/Cell Adhesion Molecule 1 Pathway Regulation of Mast Cell/Dorsal Root Ganglion Communication based on the"Xinkai-Kujiang"Method(No.82374401)。
OBJECTIVE:To explore if Hewei Jiangni granule(和胃降逆颗粒,HWJNG)could regulate esophageal hypersensitivity via stromal interaction molecule 1(STIM1)/transient receptor potential vanilloid subfamily member 1(TRPV1)pat...
关键词：non-erosive reflux disease visceral hypersensitivity stromal interaction molecule 1 transient receptor potential channels Hewei Jiangni granule 
Ion Channel Dysregulation Following Intracerebral Hemorrhage
《Neuroscience Bulletin》2024年第3期401-414,共14页Xiangyu Zhang Yan Zhang Qiuyang Su Yang Liu Zhe Li V.Wee Yong Mengzhou Xue 
supported by the National Natural Science Foundation of China(82071331,81870942,and 81520108011);the National Key Research and Development Program of China(2018YFC1312200);the Canadian Institutes of Health Research(VWY).
Injury to the brain after intracerebral hemorrhage(ICH)results from numerous complex cellular mechanisms.At present,effective therapy for ICH is limited and a better understanding of the mechanisms of brain injury is ...
关键词：Intracerebral hemorrhage Ion dyshomeostasis Sulfonylurea 1 transient receptor potential melastatin 4 TWIK-related K+channel 1 N-methyl-Daspartate receptor Transient receptor potential vanilloid 4 
Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
《World Journal of Gastroenterology》2024年第10期1431-1449,共19页Zheng-Yang Li Yu-Qing Mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang 
The Health Commission of Jinshan District,Shanghai,China,No.JSKJ-KTMS-2019-01;The Youth Research Foundation of Jinshan Hospital of Fudan University,No.JYQN-JC-202101 and No.JYQN-JC-202216;The Reserve Discipline Construction of Jinshan Hospital of Fudan University,No.HBXK-2021-2.
BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain conditions.The possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diar...
关键词：Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain 
瞬时受体电位香草酸亚家族1介导针刺治疗病理性疼痛的作用
《World Journal of Acupuncture-Moxibustion》2023年第3期204-212,共9页陈志翰 杨霖 闫国瑞 刘琪 曹娇娇 时方圆 徐枝芳 郭义 林小伟 
Supported by the National Natural Science Foundation of China:No.82030125;82105024;the National Natural Science Foundation of Tianjin:No.20JCQNJC00280;20JCQNJC00920;the Tianjin Health Commission:No.2021056。
Acupuncture,a traditional oriental intervention for chronic pain,has been gaining worldwide popularity.Transient receptor potential vanilloid subfamily 1(TRPV1)is a key factor mediating pain production and sensitizati...
关键词：Acupuncture ANALGESIA Pathological pain Transient Receptor Potential Vanilloid subfamily1(TRPV1) Molecular mechanism 
口腔鳞状细胞癌中TRPV2的表达及其临床病理意义被引量：1
《实用医学杂志》2023年第15期1913-1918,共6页王亚 张林杰 仵楠 徐江 代海涛 
国家自然科学基金资助项目(编号:82160572);石河子大学校级科研项目资助项目(编号:zzzc202194)。
目的探究口腔鳞状细胞癌(OSCC)中TRPV2的表达及其临床病理意义。方法免疫组化及Western blot检测TRPV2在OSCC中的表达水平,Pearsonχ^(2)检验分析TRPV2表达与OSCC患者临床病理的关系,Log-rank检验分析TRPV2对生存期的影响。生物信息学...
关键词：口腔鳞状细胞癌 transient receptor potential vanilloid type-2 预后 富集分析 免疫浸润 
Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1–S4 bundle rather than a quiescent state被引量：2
《Science Bulletin》2022年第10期1062-1076,M0004,共16页Meng-Yang Sun Xue Zhang Peng-Cheng Yu Di Liu Yang Yang Wen-Wen Cui Xiao-Na Yang Yun-Tao Lei Xing-Hua Li Wen-Hui Wang Peng Cao Heng-Shan Wang Michael X.Zhu Chang-Zhu Li Rui Wang Ying-Zhe Fan Ye Yu 
supported by the Natural Science Foundation of Jiangsu Province(BK20202002);the National Natural Science Foundation of China(81603409,31900808,81902480,21977021,31570832,31971146,and 31971042);Innovation and Entrepreneurship Talent Program of Jiangsu Province;State Key Laboratory of Utilization of Woody Oil Resource(2019XK2002);the Natural Science Foundation of Hunan Province(2018JJ1012);Hunan“Huxiang”High-level Talent Program(2021);“Xing Yao”Leading Scholars of China Pharmaceutical University(2021)。
Transient receptor potential vanilloid 1(TRPV1)channel plays an important role in a wide range of physiological and pathological processes,and a comprehensive understanding of TRPV1 gating will create opportunities fo...
关键词：Ligand-gated ion channels TRPV1 ALLOSTERY Voltage-clamp fluorometry Vanilloid agonist 
Beyond Thermal Sensation: Roles of Transient Receptor Potential Vanilloid Subfamily Member 1 and Spicy Food in Cardiometabolic Diseases
《Cardiology Discovery》2022年第1期1-5,共5页Zhiming Zhu 
supported by grants from the National Basic Research Program of China(2006CB503905);the National Natural Science Foundation of China(81721001,31701023,81900380).
The 2021 Nobel Prize in Physiology or Medicine was awarded to David Julius for his discovery of capsaicin receptors in 1997.[1]The capsaicin receptor is also called transient receptor potential vanilloid subfamily mem...
关键词：transient belongs SHAPED 
Distribution of transient receptor potential vanilloid-1 channels in gastrointestinal tract of patients with morbid obesity被引量：1
《World Journal of Clinical Cases》2022年第1期79-90,共12页Unal Atas Nuray Erin Gokhan Tazegul Gulsum Ozlem Elpek Bülent Yıldırım 
BACKGROUND Transient receptor potential vanilloid-1(TRPV1),a nonselective cation channel,is activated by capsaicin,a pungent ingredient of hot pepper.Previous studies have suggested a link between obesity and capsaici...
关键词：CAPSAICIN Transient receptor potential vanilloid 1 IMMUNOHISTOCHEMISTRY Morbid obesity OBESITY Transient receptor potential channels Transient receptor potential vanilloid cation channels 
ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors
《Neuroscience Bulletin》2021年第10期1381-1396,共16页Xiaodong Yan Sitao Zhang Haiyan Zhao Ping Liu Haixia Huang Weizhen Niu Wei Wang Chen Zhang 
by the National Natural Science Foundation of China(31871147 and 31371162);the Science and Technology Development Program of Beijing Municipal Education Commission(KZ202010025038).
Mechanosensitive ion channels(MSCs)are key molecules in the mechano-electrical transduction of arterial baroreceptors.Among them,acid-sensing ion channel 2(ASIC2)and transient receptor potential vanilloid subfamily me...
关键词：Acid-sensing ion channel 2 Transient receptor potential vanilloid subfamily member 1 Mechano-electrical transduction Arterial baroreceptors Synergism 
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