ALLOSTERY

作品数：11被引量：20H指数：3
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相关领域：生物学理学更多>>
相关作者：苏晓东更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Biosciences and Medicines》《Quantitative Biology》《Science China Chemistry》《Science Bulletin》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Applications of a Single Molecule Theory of Protein Dynamics
《Journal of Biosciences and Medicines》2024年第6期311-335,共25页Yi Fang 
A single molecule theory for protein dynamics has been developed since 2012. It consists of the concepts of conformational Gibbs free energy function (CGF) and single molecule thermodynamic hypothesis (STH) that claim...
关键词：FOLDING DENATURATION BINDING Post-Binding Deformation ALLOSTERY Dynamic Second Law of Thermodynamics 
Mapping allosteric pathway in NIa-Pro using computational approach
《Quantitative Biology》2023年第1期82-93,共12页Rashmi Panigrahi Senthilkumar Kailasam 
Background:Computer simulation studies complement in vitro experiments and provide avenue to understand allosteric regulation in the absence of other molecular viewing techniques.Molecular dynamics captures internal m...
关键词：NIa-Pro VPG simulation residue interaction network ALLOSTERY 
Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1–S4 bundle rather than a quiescent state被引量：2
《Science Bulletin》2022年第10期1062-1076,M0004,共16页Meng-Yang Sun Xue Zhang Peng-Cheng Yu Di Liu Yang Yang Wen-Wen Cui Xiao-Na Yang Yun-Tao Lei Xing-Hua Li Wen-Hui Wang Peng Cao Heng-Shan Wang Michael X.Zhu Chang-Zhu Li Rui Wang Ying-Zhe Fan Ye Yu 
supported by the Natural Science Foundation of Jiangsu Province(BK20202002);the National Natural Science Foundation of China(81603409,31900808,81902480,21977021,31570832,31971146,and 31971042);Innovation and Entrepreneurship Talent Program of Jiangsu Province;State Key Laboratory of Utilization of Woody Oil Resource(2019XK2002);the Natural Science Foundation of Hunan Province(2018JJ1012);Hunan“Huxiang”High-level Talent Program(2021);“Xing Yao”Leading Scholars of China Pharmaceutical University(2021)。
Transient receptor potential vanilloid 1(TRPV1)channel plays an important role in a wide range of physiological and pathological processes,and a comprehensive understanding of TRPV1 gating will create opportunities fo...
关键词：Ligand-gated ion channels TRPV1 ALLOSTERY Voltage-clamp fluorometry Vanilloid agonist 
Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells被引量：2
《Acta Pharmaceutica Sinica B》2022年第2期876-889,共14页Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng Wei Li Feng Jun-Cheng Su Yingqing Wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong Xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang 
supported by the National Natural Science Foundation of China(81925034,81903458,22077082,82003605,81901423);the Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-01-E00036,China);Shanghai Science and Technology Innovation Fundation(19431901600,China);the Shanghai Health and Family Planning System Excellent Subject Leader and Excellent Young Medical Talents Training Program(2018BR12,China);Special Financial Grant of Postdoctoral Research Foundation of China(2019M660090);。
SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeuti...
关键词：SIRT6 Molecular dynamics simulations Reversed allostery Allosteric inhibitor Pancreatic cancer Cell migration Cytokine production 
Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators被引量：3
《Acta Pharmaceutica Sinica B》2021年第11期3433-3446,共14页Yuran Qiu Yuanhao Wang Zongtao Chai Duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang Shaoyong Lu Chuan Lv Mingfei Ji 
supported in part by grants from the National Natural Science Foundation of China(22077082,21778037,81925034,91753117,and 81721004);the Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-01E00036,China);the Shanghai Science and Technology Innovation(19431901600,China);the Shanghai Health and Family Planning System Excellent Subject Leader and Excellent Young Medical Talents Training Program(2018BR12,China)。
RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state.RAS gain-of-function mutations are one of the leading causes in human oncogenesi...
关键词：RAS PHOSPHORYLATION Undruggable Protein kinases ALLOSTERY 
Self-made allostery: endogenous COMP antagonizes pathologic AT1_(A)R signaling
《Cell Research》2021年第7期730-731,共2页Ama Dedo Okyere Douglas G.Tilley 
The identification and development of biased modulators of proximal G protein-coupled receptor(GPCR)signaling to prevent pathological disease progression has been at the forefront of recent drug discovery efforts.Rece...
关键词：ENDOGENOUS AT1 COMP 
Androgen receptor co-regulation in prostate cancer被引量：4
《Asian Journal of Urology》2020年第3期219-232,共14页Dhirodatta Senapati Sangeeta Kumari Hannelore V.Heemers 
supported by DOD PCRP award W81XWH-16-1-0404(HVH);NIH NCI grant CA166440(HVH).
Prostate cancer(PCa)progression relies on androgen receptor(AR)action.Preventing AR’s ligand-activation is the frontline treatment for metastatic PCa.Androgen deprivation therapy(ADT)that inhibits AR ligand-binding i...
关键词：ANDROGEN COREGULATOR Gene transcription Hormonal therapy ALLOSTERY 
Dynamical and allosteric regulation of photoprotection in light harvesting complex Ⅱ被引量：2
《Science China Chemistry》2020年第8期1121-1133,共13页Hao Li Yingjie Wang Manping Ye Shanshan Li Deyong Li Haisheng Ren Mohan Wang Luchao Du Heng Li Gianluigi Veglia Jiali Gao Yuxiang Weng 
supported by the National Natural Science Foundation of China(21433014,11721404,21533003);the Ministry of Science and Technology(2017YFB0203400);Chinese Academy of Sciences Innovation Program(KJCX2-YW-W25);the National Institutes of Health(GM46736,GM64742)。
Major light-harvesting complex of photosystemⅡ(LHCⅡ)plays a dual role in light-harvesting and excited energy dissipation to protect photodamage from excess energy.The regulatory switch is induced by increased acidit...
关键词：LHCⅡphotoprotection conformational dynamics and allostery protein switch T-jump FTIR fluorescence quenching excited energy transfer 
Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating被引量：2
《Cell Research》2018年第12期1158-1170,共13页Guizhen Fan Mariah R. Baker Zhao Wang Alexander B. Seryshev Steven J. Ludtke Matthew L. Baker Irina I. Serysheva 
the National Institutes of Health (ROIGM072804,R21AR063255,R21NS106968, ROIGM080139,P41GM103832,American Heart Association (16GRNT2972000);Muscular Dystrophy Association (295138);National Science Foundation (DBI-1356306).
Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are cation channels that mobilize Ca2+ from intracellular stores in response to a wide range of cellular stimuli.The paradigm of InsP3R activation is the coupled interp...
关键词：CRYO-EM REVEALS LIGAND ALLOSTERY UNDERLYING InsP3R channel GATING 
Structural insights into Ca^2＋-activated long-range allosteric channel gating of RyR1被引量：5
《Cell Research》2016年第9期977-994,共18页Risheng Wei Xue Wang Yan Zhang Saptarshi Mukherjee Lei Zhang Qiang Chen Xinrui Huang Shan Jing Congcong Liu Shuang Li Guangyu Wang Yaofang Xu Sujie Zhu Alan J Williams Fei Sun Chang-Cheng Yin 
Acknowledgments We thank Dr Anthony Lai （Wales Heart Research Institute, Cardiff University School of Medicine, UK） for advice and suggestions during the course of this research and critically reading this manuscript. This research was supported by grants from the Strategic Priority Research Program of Chinese Academy of Sciences （XDB08030202 to FS）, the National Basic Research Program （973 Program）, the Ministry of Science ＆ Technology of China （Programs 2012CB917200 to CCY and 2014CB910700 to FS）, the National Natural Science Foundation of China （31270768 to CCY） and the Ministry of Education of China （111 Program China to CCY）. All the cryo-EM work and all the intensive computations were performed at Centre for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences （CBI, http：//cbi.ibp.ac.cn）, with the help from Drs Xiaojun Huang and Lunjiang Lin.
Ryanodine receptors （RyRs） are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These channels mediate calcium signaling in a variety of cells. Since more than 80% of the RyR protein is folde...
关键词：Ca^2＋ activation cryo-electron microscopy channel gating ion selectivity long-range allostery ryanodine receptor single-particle analysis 
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