COREGULATOR

作品数：6被引量：9H指数：2
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相关领域：医药卫生更多>>
相关作者：郝翠芳刘振腾更多>>
相关机构：烟台毓璜顶医院更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《癌症》《Chinese Medical Journal》更多>>
相关基金：国家自然科学基金更多>>
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Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer
《Chinese Medical Journal》2023年第21期2576-2586,共11页Jie Liu Zhiqi Wang Jingyi Zhou Jiaqi Wang Xiangjun He Jianliu Wang 
supported by grants from the National Key Technology R&D Program of China(Nos.2019YFC1005200 and 2019YFC1005201).
Background:Steroid receptor-associated and regulated protein(SRARP)suppresses tumor progression and modulates steroid receptor signaling by interacting with estrogen receptors and androgen receptors in breast cancer.I...
关键词：SRARP Progesterone receptor Epithelial-mesenchymal transition COREGULATOR Tumor suppressor Endometrial cancer 
Androgen receptor co-regulation in prostate cancer被引量：4
《Asian Journal of Urology》2020年第3期219-232,共14页Dhirodatta Senapati Sangeeta Kumari Hannelore V.Heemers 
supported by DOD PCRP award W81XWH-16-1-0404(HVH);NIH NCI grant CA166440(HVH).
Prostate cancer(PCa)progression relies on androgen receptor(AR)action.Preventing AR’s ligand-activation is the frontline treatment for metastatic PCa.Androgen deprivation therapy(ADT)that inhibits AR ligand-binding i...
关键词：ANDROGEN COREGULATOR Gene transcription Hormonal therapy ALLOSTERY 
Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis被引量：5
《Chinese Journal of Cancer》2017年第3期139-149,共11页Liang Du Zhifeng Ning Fuxing Liu Hao Zhang 
supported in part by the National Natural Science Foundation of China(Nos.81071736,30973508,and 81572876);the Clinical Research Enhancement Initiative of Shantou University Medical College(Nos.201412 and 201421);the Collaborative and Creative Center,Molecular Diagnosis and Personalized Medicine,Shantou University,Guangdong Province,and the Department of Education,Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases(Nos.2015072,2015065,2015020,and 2015077)
Worldwide,metastasis is the leading cause of more than 90%of cancer-related deaths.Currently,no specific therapies effectively impede metastasis.Metastatic processes are controlled by complex regulatory networks and t...
关键词：METASTASIS associated PROTEINS COREGULATOR NuRD complex Master REGULATOR 
Regulation of the nongenomic actions of retinoid X receptor-a by targeting the coregulator-binding sites
《Acta Pharmacologica Sinica》2015年第1期102-112,共11页Xiao-kun ZHANG Ying SU Liqun CHEN Fan CHEN Jie LIU Hu ZHOU 
Retinoid X receptor-a （RXRa）, a unique member of the nuclear receptor superfamily, represents an intriguing and unusual target for pharmacologic interventions and therapeutic applications in cancer, metabolic disord...
关键词：RXRa rexinoid RXRa MODULATOR NONGENOMIC action COREGULATOR site apoptosis inflammation PI3K NSAID 
Dialogue between estrogen receptor and E2F signaling pathways: The transcriptional coregulator RIP140 at the crossroads
《Advances in Bioscience and Biotechnology》2013年第10期45-54,共10页Marion Lapierre Aurélie Docquier Audrey Castet-Nicolas Stéphan Jalaguier Catherine Teyssier Patrick Augereau Vincent Cavaillès 
Estrogen receptors and E2F transcription factors are the key players of two nuclear signaling pathways which exert a major role in oncogenesis, particularly in the mammary gland. Different levels of dialogue between t...
关键词：RIP140 E2F Transcription Factors ESTROGEN Receptors Gene Expression Cell Proliferation Breast Cancer ENDOCRINE THERAPIES 
Androgen receptor coregulator ARA267-α interacts with death receptor-6 revealed by the yeast two-hybrid
《Science China(Life Sciences)》2004年第5期442-448,共7页MAI Tiejun WANG Xin ZHANG Zhiwen XIN Dianqi NA Yanqun GUO Yinglu 
This work was supported by National Nature Science Foundation of China(Grant No.30120007);the National Special Fund for“211 Project”of China(Grant No.217).
ARA267-a is a newly identified androgen receptor coactivator. In order to further elucidate its precise role in cells, using the ARA267- a fragment containing four PHD and one SET conserved domains as bait we revealed...
关键词：ARA267-a androgen receptor androgen receptor coregulator death receptor-6 yeast two-hybrid system 
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