云南高校图书馆联盟文献共享服务平台- E2F

E2F: 作品数：100被引量：170H指数：7; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：韩梅温进坤黄怡吴琼廖柳凤更多>>; 相关机构：北京大学中南大学浙江大学华中科技大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广西壮族自治区自然科学基金中国博士后科学基金更多>>

miR-221-5p靶向调控E2F3对结肠癌细胞增殖、迁移的影响: 《中国老年学杂志》2025年第6期1479-1485,共7页周昱杜旭东; 目的探讨miR-221-5p抑制结肠癌细胞增殖、迁移的作用及相关机制。方法稳定培养HT-29、SW480细胞,分别过表达miR-221-5p和(或)敲低E2F转录因子(E2F)3表达,细胞分为miR-NC组、miR-221-5p组、si-NC组、si-E2F3组、miR-NC+si-NC组、miR-NC+s...; 关键词：结肠癌 miR-221-5p 非编码RNA E2F转录因子(E2F)3

LA-D靶向CDK4/6-Cyclin D1-Rb-E2F通路对乳腺癌细胞的抑制功能: 《江苏海洋大学学报(自然科学版)》2025年第1期71-80,共10页刘媛媛李寒雪张思懿左玲怡周娇娇姜文韬刘志晴张美琪成文浩敬爱新袁庆刘彬; 乳腺癌是一种常见的恶性肿瘤,发病率较高,主要发生在女性乳腺组织中。设计并合成了一种新型Abemaciclib衍生物6-((2-氯-4-((5-氟-4-(4-氟-1-异丙基-2-甲基-1H-苯并[d]咪唑-6-基)嘧啶-2-基)氨基)苯氧基)甲基)吡啶腈(LA-D)。通过MTT试验...; 关键词：LA-D 乳腺癌迁移侵袭抗肿瘤活性

Notch调节Rb-E2F信号通路物理机制的模型化研究: 《伊犁师范大学学报(自然科学版)》2024年第4期41-50,共10页郭秀珍苏瑞赵新军; 伊犁师范大学微纳电传感与仿生器械平台开放课题一般项目(2023YSWN05);伊犁师范大学科研创新团队培育计划(CXZK2021022)资助课题.; Notch-Jagged信号对Myc-E2F通路的调控动力学机制,一直缺乏完整系统的理解.本文基于质量作用原理、Hill动力学与Michaelis-Menten方程,建立较为完整的理论模型,研究Notch调节Rb-E2F信号通路的一种物理机制.通过分析Notch信号对Rb-E2F信...; 关键词：NOTCH 调节 Rb-E2F信号通路

E2F转录因子家族在消化道恶性肿瘤中的作用: 《临床肿瘤学杂志》2024年第11期1114-1120,共7页杨帅闫文娴朱超赵文飞冯青青赵文文魏红梅; E2F2s是一种重要的转录因子,与消化道肿瘤的发生和发展密切相关。消化道肿瘤是一类常见的恶性肿瘤,包括食管癌、胃癌、结直肠癌等,严重威胁人们健康。研究表明,E2F2s在消化道肿瘤中起关键作用。E2F2s调控细胞周期转变和基因表达,影响细...; 关键词：消化道肿瘤 E2Fs 靶基因治疗靶点

E2F转录因子家族在脂肪生成中的调控作用: 《高师理科学刊》2024年第8期90-95,共6页李美琦孔令喆杜金铭崔金妍孙婴宁; 黑龙江省自然科学基金项目(YQ2019C025);黑龙江省省属本科高校优秀青年教师基础研究支持计划项目(YQJH2023103);齐齐哈尔大学2023-2024年度研究生创新科研项目(QUZLTS_CX2023026)。; E2F转录因子(E2F transcription factor,E2Fs)是视网膜母细胞瘤蛋白(Retinoblastoma protein,p Rb,RB或RB1)家族的主要靶蛋白.作为关键的转录因子家族成员,E2Fs在调控下游基因的转录、DNA合成和细胞周期中起到至关重要的作用.近年来,关...; 关键词：E2F转录因子脂肪生成小鼠胚胎成纤维细胞

Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer: 《Chinese Medical Journal》2024年第15期1844-1856,共13页Yue Ge Sheng Ma Qiang Zhou Zezhong Xiong Yanan Wang Le Li Zheng Chao Junbiao Zhang Tengfei Li Zixi Wu Yuan Gao Guanyu Qu Zirui Xi Bo Liu Xi Wu Zhihua Wang; supported by the National Natural Science Foundation of China(Nos.82173068,81974400);the Applied Basic Research Plan from Qinghai Provincial Department of Science and Technology(No.2021-ZJ-723).; Background:Although some well-established oncogenes are involved in cancer initiation and progression such as prostate cancer(PCa),the long tail of cancer genes remains to be defined.Goosecoid(GSC)has been implicated ...; 关键词：GOOSECOID Prostate cancer Prognosis E2F transcription factor 1 Trametinib

RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells被引量：1: 《Genes & Diseases》2024年第3期55-58,共4页Chengyu Li Deyuan Pan Wan Lin Danxia Deng Yingxin Zhou Hui Zhao Feng Pan Liyan Xu Enmin Li Lin Long; supported by grants from National Natural ScienceFoundationof China(No.82002975 and No.82173011);Special Fund for Science and Technology of Guangdong Province(No.200105215896551).; Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accoun...; 关键词：cancer ESOPHAGEAL ESOPHAGEAL

Aquaporin 1 overexpression may enhance glioma tumorigenesis by interacting with the transcriptional regulation networks of Foxo4,Maz,and E2F families: 《Chinese Neurosurgical Journal》2024年第1期20-27,共8页Ying Guan Jinhua Han Die Chen Yuefu Zhan Jianqiang Chen; supported by Natural Science Foundation of Hainan Province(821RC692);Hainan Provincial Health Industry Research Project(20A200136);Hainan Natural Science Foundation(2019RC388); Background The glioblastoma has served as a valuable experimental model system for investigating the growth and invasive properties of glioblastoma.Aquaporin-1(AQP1)in facilitating cell migration and potentially contr...; 关键词：C6 cell line Aquaporin 1 Gioma Migration

Long non-coding RNA CDKN2B-AS1 promotes hepatocellular carcinoma progression via E2F transcription factor 1/G protein subunit alpha Z axis: 《World Journal of Gastrointestinal Oncology》2023年第11期1974-1987,共14页Zhi-Gang Tao Yu-Xiao Yuan Guo-Wei Wang; BACKGROUND A series of long non-coding RNAs(lncRNAs)have been reported to play a crucial role in cancer biology.Some previous studies report that lncRNA CDKN2B-AS1 is involved in some human malignancies.However,its ro...; 关键词：Hepatocellular carcinoma CDKN2B-AS1 E2F transcription factor 1 G protein subunit alpha Z Proliferation

E2F transcription factors and their complementary roles during DNA damage responses: 《Molecular Plant》2023年第9期1373-1375,共3页Paula Casati; E2F transcription factors(TF)comprise a family of proteins that regulate the expression of genes required for S-phase progression,among others.Arabidopsis genome encodes six E2F TFs(E2FA–F),which are classified as ty...; 关键词：DAMAGE E2F COMPLEMENTARY

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