E2F transcription factors and their complementary roles during DNA damage responses  

作　　者：Paula Casati 

机构地区：[1]Centro de Estudios Fotosinteticos y Bioquimicos(CEFOBl),Universidad Nacional de Rosario,Suipacha 531,2000 Rosario,Argentina

出　　处：《Molecular Plant》2023年第9期1373-1375,共3页分子植物（英文版）

摘　　要：E2F transcription factors(TF)comprise a family of proteins that regulate the expression of genes required for S-phase progression,among others.Arabidopsis genome encodes six E2F TFs(E2FA–F),which are classified as typical(E2FA–C)and atypical(E2FD–F)depending on their ability to interact with two DP interaction proteins(DPa and DPb)(Sablowski and Gutierrez,2022).While E2FA–C need to heterodimerize with either DPa or DPb to function,E2FD–F act independently of DP proteins.Moreover,the retinoblastoma-related1(RBR1)protein also binds and inhibits the typical E2F/DP TF complexes when bound to the promoter of genes,repressing their expression in the absence of a signal to enter a new cell cycle.In general,E2FA and E2FB are considered transcriptional activators,while E2FC is generally considered a repressor of cell proliferation(Sablowski and Gutierrez,2022).In addition,it is well documented that E2FB at least,and probably E2FA,can also stimulate the G2/M transition.

关 键 词：DAMAGE E2F COMPLEMENTARY 

分 类 号：R73[医药卫生—肿瘤]