奥沙西泮对3种乙醛脱氢酶2基因型酒精依赖综合征患者的治疗效果  

Efficacy of oxazepam in treating 3 types of aldehyde dehydrogenase-2 gene carriers in patients with alcohol dependence syndrome

作　　者：张海庆[1] 张少川[1] 黄秋燕 何林 张旭兰[2] ZHANG Haiqing;ZHANG Shaochuan;HUANG Qiuyan;HE Lin;ZHANG Xulan(Medical Laboratory Department of Yunnan Psychiatric Hospital,Kunming 650224,Yunnan,China;Department of Alcohol and Drug dependence,Yunnan Psychiatric Hospital,Kunming 650224,Yunnan,China)

机构地区：[1]云南省精神病医院医学检验科,云南昆明650224 [2]云南省精神病医院酒与药物依赖治疗科,云南昆明650224

出　　处：《贵州医科大学学报》2022年第3期353-357,362,共6页Journal of Guizhou Medical University

基　　金：昆明市卫生科技人才培养暨内设研究机构/技术中心建设科研项目(SW〔技〕-02)。

摘　　要：目的探讨奥沙西泮对3种乙醛脱氢酶2(ALDH2)基因型酒精依赖综合征(ADS)的治疗效果。方法106例行奥沙西泮治疗的ADS患者根据ALDH 2基因分型分为基因1型组((ALDH 2×1/×1,n=47)、基因2型组(ALDH 2×1/×2,n=35)及基因3型组(ALDH 2×2/×2,n=24);比较3组患者入院和治疗第7天时的酒精依赖戒断综合征(AWS)评分、焦虑自评量表(SAS)评分、匹兹蛋睡眠质量指数(PSQI)评分及血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、谷酰转肽酶(GGT)水平,比较3组患者出院半年时的复饮率和再住院率。结果3组患者治疗第7天时的AWS评分、SDS评分、SAS评分、PSQI评分及血清ALT、AST、ALP、GGT水平均较治疗前降低,差异有统计学意义(P<0.05);且在治疗前及治疗第7天时,3组患者AWS评分、SDS评分、SAS评分、PSQI评分及血清ALT、AST、ALP、GGT水平比较,基因3型组>基因2型组>基因1型组,差异有统计学意义(P<0.05);出院半年后,基因1型组和基因2型组ADS患者复饮率低于基因3型组,基因1型组再住院率ADS患者降低基因3型组,差异有统计学意义(P<0.05)。结论奥沙西泮对3种ALDH 2基因型ADS患者的治疗均有效,但治疗效果存在差异。Objective To investigate the clinical efficacy of oxazepam in treating 3 types of aldehyde dehydrogenase-2(ALDH 2)gene carriers in patients with alcohol dependence syndrome(ADS).Methods One hundred and six patients with ADS were treated with oxazepam.According to ALDH 2 genotyping,all patients were divided into Geno type-1 group(ALDH 2×1/×1,n=47),Geno type-2 group(ALDH 2×1/×2,n=35),and Geno type-3 group(ALDH 2×2/×2,n=24).The following indexes of three groups first admitted to hospital and 7 d after treatment were compared:AWS score,SAS score,and PSQI score,as well as levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and r-glutamyle transpeptidase(GGT);in addition,re-drinking rate and rehospitalization rate of 3 groups were compared.Results The AWS score,SDS score,SAS score,and PSQI score,as well as serum indexes(ALT,AST,ALP,and GGT levels)of 3 groups 7 days after treatment were significantly lower than those before treatment,differences were statistically significant(P<0.05).Before and on 7 th day after treatment,comparison of AWS score,SDS score,SAS score,and PSQI score as well as serum indexes(ALT,AST,ALP,and GGT levels)showed Geno type-3 group>Geno type-2 group>Geno type-1 group,differences were statistically significant(P<0.05).After discharged from hospital for half a year,Geno type-1 and type-2 group showed lower re-drinking rate than that of Geno type-3 group,Geno type-1 group showed lower rehospitalization rate than that of type-3 group,differences were statistically significant(P<0.05).Conclusions Oxazepam is effective in the treatment of 3 types of ALDH 2 gene carriers in patients with ADS,while efficacy shows differentiated results.

关 键 词：奥沙西泮 酒精依赖综合征 乙醛脱氢酶2基因 酒精依赖戒断综合征评分 肝功能 治疗效果 

分 类 号：R749.6[医药卫生—神经病学与精神病学]