原发性肝癌高危人群的早期预警和精准筛查  

Early warning and accurate screening for the high-risk population of hepatocellular carcinoma

作　　者：郝新 樊蓉[1] 侯金林[1,2] HAO Xin;FAN Rong;HOU Jinlin(Department of Infectious Diseases,Nanfang Hospital of Southern Medical University,State Key Laboratory of Organ Failure Research,Guangdong Provincial Key Laboratory of Viral Hepatitis Research,Guangzhou 510515,China;Hepatology Unit,Shenzhen Hospital,Southern Medical University,Shenzhen,Guangdong 518000,China)

机构地区：[1]南方医科大学南方医院感染内科,器官衰竭研究国家重点实验室,广东省病毒性肝炎研究重点实验室,广州510515 [2]南方医科大学深圳医院肝病中心,广东深圳518000

出　　处：《临床肝胆病杂志》2022年第3期499-504,共6页Journal of Clinical Hepatology

基　　金：深圳市医药卫生“三名工程”高层次医学团队项目(SZSM201911001)。

摘　　要：对我国慢性肝病人群开展规范筛查,实现肝癌危险人群精准分层与规范管理,并通过有效技术手段早期预警肝癌,是提升我国肝癌早期诊断率的有效方法。临床实践中可以利用aMAP等肝癌风险评分模型对慢性肝病人群进行风险初筛,识别罹患肝癌中、高危人群,通过新型血清标志物进一步鉴定出肝癌极高危人群,并应用影像学技术早诊筛查。通过分层富集,不断探索、完善肝癌早筛早诊“金字塔”筛查管理模式,以最终实现提高肝癌早期诊断率并降低肝癌相关病死率的目标。It is an effective way to improve the early diagnosis rate of hepatocellular carcinoma(HCC)in China by conducting standardized screening among the population with chronic liver diseases,achieving accurate stratification and standardized management of the population at a risk of HCC,and realizing the early warning for HCC through effective technical means.In clinical practice,the risk scoring models for liver cancer including aMAP can be used for preliminary risk screening of the population with chronic liver diseases to identify the population with a moderate or high risk of liver cancer.Novel serum biomarkers can be used to further screen out the population with an extremely high risk of liver cancer,and then imaging technology can be used for early diagnosis.Constant exploration and improvement of the“pyramid”screening and management mode through stratified enrichment may help to achieve the goal of improving early diagnosis rate of HCC and reducing HCC-related mortality.

关 键 词：癌 肝细胞 筛查 早期诊断 

分 类 号：R73[医药卫生—肿瘤]