原发性胆汁性胆管炎的病理学分期系统  

Pathological staging systems of primary biliary cholangitis

作　　者：宋欣航 于涓翰 程肇平 邵晨[4] 邓宝成[1] SONG Xinhang;YU Juanhan;CHENG Zhaoping;SHAO Chen;DENG Baocheng(Department of Infectious Diseases,The First Affiliated Hospital of China Medical University,Shenyang 110000,China;Department of Pathology,School of Basic Medical Sciences,China Medical University,Shenyang 110000,China;Department of Pathology,Ankang Central Hospital,Ankang,Shaanxi 725000,China;Department of Pathology,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]中国医科大学附属第一医院传染科,沈阳110000 [2]中国医科大学基础医学院病理教研室,沈阳110000 [3]安康市中心医院病理科,陕西安康725000 [4]首都医科大学附属北京佑安医院病理科,北京100069

出　　处：《临床肝胆病杂志》2022年第3期653-655,共3页Journal of Clinical Hepatology

基　　金：辽宁省科学技术计划(2019JH2/10300031);国家“十三五”科技重大专项(2017ZX10103007)。

摘　　要：原发性胆汁性胆管炎(PBC)是一种伴有胆汁淤积的慢性自身免疫性肝脏疾病,其组织学特征为非化脓性胆管炎。本文简述了传统的PBC病理分期系统如Rubin分期、Scheuer分期以及Ludwig分期和最新的Nakanuma分期各自的优点和局限性,其中Nakanuma分期细化了组织学分级分期标准,减少因采样误差而漏诊的机会,从而为临床提供更充分的诊断及预后信息。新旧分期系统结合应用更有利于指导PBC的诊治和相关研究。Primary biliary cholangitis(PBC)is a chronic autoimmune liver disease accompanied by cholestasis,with the histological feature of non-purulent cholangitis.This article briefly describes the advantages and limitations of the traditional pathological staging systems such as Rubin stage,Scheuer stage,and Ludwig stage and the latest Nakanuma stage.Among them,Nakanuma stage refines the histological grading and staging standards to reduce the chance of missed diagnosis due to sampling errors,thus providing more adequate diagnostic and prognostic information for the clinic.A combination of new and traditional staging systems can provide guidance to the diagnosis,treatment,and research of PBC.

关 键 词：原发性胆汁性胆管炎 病理学 分期 

分 类 号：R57[医药卫生—消化系统]