肠道菌群失衡在肝癌发生发展中的影响机制及益生菌对肝癌的预防作用  

Mechanism of intestinal flora imbalance in the development and progression of liver cancer and the role of probiotics in preventing liver cancer

作　　者：高艳颖[1] 向慧玲[1] 梁静[1] 韩涛[1] 张旭[1] GAO Yanying;XIANG Huiling;LIANG Jing;HAN Tao;ZHANG Xu(Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Artificial Cell Engineering Technology Research Center,Tianjin Institute of Hepatobiliary Disease,Tianjin Third Central Hospital,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院,天津市重症疾病体外生命支持重点实验室,天津市人工细胞工程技术研究中心,天津市肝胆疾病研究所,天津300170

出　　处：《临床肝胆病杂志》2022年第3期699-702,共4页Journal of Clinical Hepatology

基　　金：天津科技重大专项与工程重大疾病防治(19ZXDBSY00030)。

摘　　要：肠道菌群失衡在肝癌的发生发展过程中起到一定作用,而益生菌对肝癌具有一定影响,二者均是临床的研究热点。本文介绍了肠道菌群失衡在肝癌发病中的作用机制以及益生菌对肝癌的预防效果。肠道菌群失衡可通过激活Toll样受体4、调控代谢物水平、产生内毒素、诱发细菌移位和小肠细菌过度增长等机制参与肝癌的病理过程;而益生菌可通过维持肝肠循环、增强免疫功能、促进肠道益生菌繁殖、降低致癌物毒性等机制发挥有效预防肝癌的作用,其可作为后续临床肝癌预防工作的重点方向进行深入研究。Intestinal flora imbalance plays a certain role in the development and progression of liver cancer,while probiotics have a certain impact on liver cancer,both of which are the focus of clinical research.This article introduces the mechanism of action of intestinal flora imbalance in the pathogenesis of liver cancer and the preventive effect of probiotics against liver cancer.Intestinal flora imbalance can participate in the pathological process of liver cancer by activating Toll-like receptor 4,regulating the level of metabolites,producing endotoxin,and inducing bacterial translocation and intestinal bacterial overgrowth,while probiotics can effectively prevent liver cancer by maintaining enterohepatic circulation,enhancing immune function,promoting the reproduction of intestinal probiotics,and reducing the toxicity of carcinogens,which can be further studied as the focus of subsequent liver cancer prevention in clinical practice.

关 键 词：肝肿瘤 胃肠道微生物组 鼠李糖乳杆菌 

分 类 号：R73[医药卫生—肿瘤]