两种方法治疗重度非增殖型糖尿病视网膜病变的疗效分析  

Efficacy Analysis of Two Methods in the Treatment of Severe Non-Proliferative Diabetic Retinopathy

作　　者：刘腾 程飞 杨品娇 贾云琴 韩佩宴 陶涛 段直光 Liu Teng;Cheng Fei;Yang Pinjiao;Jia Yunqin;Han Peiyan;Tao Tao;Duan Zhiguang(Clinical College,Dali University,Dali,Yunnan 671000,China;Department of Ophthalmology,The People's Hospital ofDali Bai Autonomous Prefecture,Dali,Yunnan 671000,China)

机构地区：[1]大理大学临床医学院,云南大理671000 [2]大理白族自治州人民医院眼科,云南大理671000

出　　处：《大理大学学报》2022年第2期51-56,共6页Journal of Dali University

基　　金：大理州科技计划项目(大科计〔2017〕号社会发展D2017SA02)。

摘　　要：目的:评价单纯广泛视网膜光凝术(PRP)和玻璃体腔注射康柏西普联合PRP治疗重度非增殖型糖尿病视网膜病变(NPDR)的临床疗效。方法:将59例(84眼)重度NPDR患者随机分为联合组33例(48眼)和对照组26例(36眼),联合组行玻璃体腔注射康柏西普联合PRP,对照组行PRP,分析比较两组患者治疗后最佳矫正视力(BCVA)、黄斑中心凹厚度(CFT)和生活质量评分。结果:两组患者治疗后BCVA和CFT均优于治疗前,差异具有统计学意义(P<0.05);联合组治疗后BCVA和CFT均优于对照组,差异具有统计学意义(P<0.05);联合组治疗使用的激光能量、光斑数量和能量密度均低于对照组,差异具有统计学意义(P<0.05);联合组患者生活质量评分高于对照组,差异具有统计学意义(P<0.05)。结论:康柏西普玻璃体腔注射药物联合PRP治疗NPDR,可以用相对较少的激光能量在较短时间内抑制视网膜新生血管生长、促进黄斑水肿吸收、使患者视功能得到改善,其治疗效果明显好于单纯应用PRP治疗。Objective:To evaluate the clinical efficacy of pure panretinal photocoagulation(PRP)and intravitreal injection of Conbercept combined with PRP in the treatment of severe non-proliferative diabetic retinopathy(NPDR).Methods:59 patients(84 eyes)with severe NPDR were randomly divided into a combination group of 33 cases(48 eyes)and a control group of 26 cases(36 eyes).The combination group received intravitreal injection of Conbercept combined with PRP,while the control group received PRP.The best corrected visual acuity(BCVA),central foveal thickness(CFT)and quality of life score between the two groups of patients after treatment were analyzed and compared.Results:The BCVA and CFT of the two groups of patients after treatment were better than those before treatment,and the differences were statistically significant(P<0.05);after treatment,the BCVA and CFT of the combined group were better than those of the control group,and the differences were statistically significant(P<0.05);the laser energy,number of spots and energy density used in the treatment of the combination group were lower than those of the control group,and the differences were statistically significant(P<0.05);the quality of life score of patients in the combination group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Conbercept intravitreal injection combined with PRP to treat NPDR can use relatively less laser energy to inhibit the growth of retinal neovascularization,promote the absorption of macular edema and improve the visual function of patients in a short time,so its therapeutic effect is significantly better than pure PRP treatment.

关 键 词：非增殖型糖尿病视网膜病变 康柏西普 广泛视网膜光凝术 

分 类 号：R77[医药卫生—眼科]