干性年龄相关性黄斑变性发病机制及治疗  

Pathogenesis and treatment of dry age-related macular degeneration

作　　者：张敬法 张宇萌 孙晓东[1] ZHANG Jingfa;ZHANG Yumeng;SUN Xiaodong(Department of Ophthalmology,Shanghai General Hospital(Shanghai First People’s Hospital),Shanghai Jiao Tong University,School of Medicine,Shanghai 200080,China)

机构地区：[1]上海市第一人民医院眼科,200080

出　　处：《眼科新进展》2022年第3期169-178,共10页Recent Advances in Ophthalmology

基　　金：国家自然科学基金项目(编号:82171076,82171062);上海市科学技术委员会项目(编号:19495800700)。

摘　　要：目前,干性年龄相关性黄斑变性尚无有效的治疗方法,但近年的临床试验显示出巨大的治疗前景,包括饮食疗法、抗体疗法、基因治疗、细胞治疗和激光治疗等。本文就干性年龄相关性黄斑变性的病理特征、发病机制和治疗方法等进行述评,以期为干性年龄相关性黄斑变性的预防和治疗提供新思路。At present, there are no effective treatments available for dry age-related macular degeneration(dry AMD), but recent clinical trials have shown great therapeutic promise, such as dietary therapy, antibody therapy, gene therapy, cell therapy, and laser therapy. This paper summarizes the pathological characteristics, pathogenesis, and therapies of dry AMD, aiming to provide new opinions for the prevention and treatment of dry AMD.

关 键 词：干性年龄相关性黄斑变性 玻璃疣 地图样萎缩 细胞治疗 基因治疗 

分 类 号：R774.5[医药卫生—眼科]