三磷酸腺苷结合盒转运体A1的组织特异性功能与动脉粥样硬化  

The tissue specific function of ATP-binding cassette transporter A1 and atherosclerosis

作　　者：丁芳芳 杨燕[1] 刘立民[1] 赵颖[1] DING Fangfang;YANG Yan;LIU Limin;ZHAO Ying(Department of Pathology and Pathophysiology,Soochow University,Suzhou,Jiangsu 215123,China)

机构地区：[1]苏州大学病理与病理生理学系,江苏省苏州市215123

出　　处：《中国动脉硬化杂志》2022年第4期357-363,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81970371);江苏高校优势学科建设工程资助项目。

摘　　要：动脉粥样硬化是一种脂质沉积引发的慢性血管炎症。动脉粥样硬化的发生发展与细胞胆固醇稳态的破坏密切相关。三磷酸腺苷结合盒转运体A1(ABCA1)介导了细胞胆固醇流出至载脂蛋白AⅠ、preβ高密度脂蛋白(HDL)和HDL_(3)。当该通路胆固醇流出障碍可致细胞内胆固醇沉积。更重要的是,ABCA1的功能障碍还影响着动脉粥样硬化斑块的生长及临床冠心病的发生。最近研究显示ABCA1对动脉粥样硬化的调控作用具有组织特异性。本文介绍了胆固醇逆向转运与动脉粥样硬化的相关性,并着重讨论了ABCA1的组织特异性功能及其调控动脉粥样硬化的作用和机制。Atherosclerosis is a chronic vascular inflammation caused by lipid deposition.The onset and progression of atherosclerotic lesions are closely related to the disturbance of cellular cholesterol homeostasis.ATP-binding cassette transporter A1(ABCA1)mediates active cholesterol efflux to apolipoprotein AⅠ,preβhigh density lipoprotein(HDL),and HDL_(3).The impairment of this cholesterol efflux pathway leads to the intracellular accumulation of cholesterol esters.Importantly,loss-of-function mutations of ABCA1 influence the growth of atherosclerotic plaques and the incidence of coronary heart diseases.Recent studies using transgenic animals have shown that effects of ABCA1 on atherosclerosis are tissue/cell-specific.This paper focuses on the role of tissue/cell-specific ABCA1 in atherosclerosis and underlying mechanisms after briefly introducing reverse cholesterol transport and atherosclerosis.

关 键 词：胆固醇 动脉粥样硬化 三磷酸腺苷结合盒转运体A1 组织特异性 

分 类 号：R363[医药卫生—病理学]