西安地区1万例门诊和体检人群幽门螺杆菌感染现状调查与危险因素分析  

Investigation and analysis of risk factors for Helicobacter pylori infection in 10016 examined populations in Xi'an

作　　者：狄佳[1] 常丹燕[2] 刘莎[1] 毛莎莎 李晚晚 屈伟[1] 郑向红[1] DI Jia;CHANG Danyan;LIU Sha;MAO Shasha;LI Wanwan;QU Wei;ZHENG Xianghong(Department of Nuclear Medicine,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,710004,China;Department of Gastroenterology,the Second Affiliated Hospital of Xi'an Jiaotong University;Development Center for Medical Science and Technology,National Health Commission of China)

机构地区：[1]西安交通大学第二附属医院核医学科,西安710004 [2]西安交通大学第二附属医院消化内科 [3]国家卫生健康委医药卫生科技发展研究中心

出　　处：《中国中西医结合消化杂志》2022年第3期200-206,共7页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：目的:调查西安地区门诊与体检人群幽门螺杆菌(Hp)感染的流行病学特征,分析相关危险因素。方法:收集2016年9月-2020年12月于西安交通大学第二附属医院行^(13)C尿素呼气试验的门诊与体检人群的临床资料,完成基本情况的单因素分析、影响因素的单因素分析、危险因素的logistic回归分析。结果:在10016例门诊与体检人群中,Hp感染阳性3255例,感染率为32.50%。基本情况的单因素分析示,各年龄段Hp感染率差异有统计学意义(P<0.05),老年组感染率最高,其次为中年及青年组。男性、少数民族、农村地区Hp感染率显著高于女性、汉族、城市地区,差异均有统计学意义(P<0.01)。工人、农民、服务人员人群的整体Hp感染率最高,其次为学生、自由职业者人群,最低为公职人员、医护人员、教师人群,差异均有统计学意义(P<0.01)。不同婚姻状况人群Hp感染率差异无统计学意义(P>0.05)。影响因素的单因素分析示,有消化系统症状、不洁饮食史、吸烟史、饮酒史.Hp感染家族史、冠心病史人群的Hp感染率显著高于无消化系统症状、卫生饮食、无吸烟史.无饮酒史、无Hp感染家族史、非冠心病者,差异均有统计学意义(P<0.01)。各体质指数(BMI)异常组Hp感染率显著高于BMI正常组,差异均有统计学意义(P<0.01),BMI肥胖组Hp感染率最高,其次为BMI超重组及过轻组。有胃镜报告及糖尿病史人群Hp感染率差异无统计学意义(P>0.05)。logistic回归分析示,居住地区、消化系统症状、BMI、不洁饮食史、饮酒史、Hp感染家族史均为Hp感染的独立危险因素(P<0.01)。而年龄、性别、民族、职业、吸烟史、冠心病史虽然影响Hp感染率,但差异无统计学意义(P>0.05)。结论:西安地区门诊与体检人群Hp感染率为32.50%,Hp感染的独立危险因素为居住地区、消化系统症状、BMI.不洁饮食史、饮酒史及Hp感染家族史。Objective: To investigate the epidemiological characteristics of Helicobacter pylori(Hp) infection in outpatients and physical examination population in Xi’an and analyze related risk factors. Methods: The clinical data of outpatients and physical examination populations who underwent ^(13)C urea breath test in the Second Affiliated Hospital of Xi’an Jiaotong University from September 2016 to December 2020 were collected, and complete single factor analysis of basic conditions and influencing factors, and finish logistic regression analysis were completed. Results: Among 10 016 outpatients and physical examinations, 3255 Hp infections were positive, and the infection rate was 32.50%. Univariate analysis of the basic situation showed that the Hp infection rate of each age group had a statistically significant difference(P<0.05). The infection rate of the elderly group was the highest, followed by the middle-aged and young groups. The infection rates of Hp in men, ethnic minorities, and rural areas were significantly higher than that in female, the Han nationality, urban areas, and the differences were statistically significant(all P<0.01). The overall Hp infection rate among workers, farmers, and service personnel was the highest, followed by students and freelancers, and the lowest among public officials, medical staff, and teachers. The differences were statistically significant(all P<0.01). There was no significant difference in Hp infection rate among people with different marital status groups(P>0.05). A single factor analysis of influencing factors showed that Hp infection rates of people with digestive symptoms, history of unclean diet, smoking, drinking, family history of Hp infection, and history of coronary heart disease were significantly higher than that of people without digestive system symptoms, history of unclean diet, smoking, drinking, family history of Hp infection, and coronary heart disease(P<0.01). The infection rate of Hp in each abnormal body mass index(BMI) group was significantly high

关 键 词：幽门螺杆菌 感染率 流行病学 危险因素 相关性 

分 类 号：R573.6[医药卫生—消化系统]