SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells  

作　　者：Daniel Perez-Zsolt Jordana Muñoz-Basagoiti Jordi Rodon Marc Elosua-Bayes Dàlia Raïch-Regué Cristina Risco Martin Sachse Maria Pino Sanjeev Gumber Mirko Paiardini Jakub Chojnacki Itziar Erkizia Xabier Muñiz-Trabudua Ester Ballana Eva Riveira-Muñoz Marc Noguera-Julian Roger Paredes Benjamin Trinité Ferran Tarrés-Freixas Ignacio Blanco Victor Guallar Jorge Carrillo JuliàBlanco Amalio Telenti Holger Heyn Joaquim Segalés Bonaventura Clotet Javier Martinez-Picado Júlia Vergara-Alert Nuria Izquierdo-Useros 

机构地区：[1]IrsiCaixa AIDS Research Institute,089,Badalona,Spain [2]IRTA,Centre de Recerca en Sanitat Animal(CReSA,IRTA-UAB),Campus de la UAB,08193,Bellaterra(Cerdanyola del Vallès),Spain [3]CNAG-CRG,Centre for Genomic Regulation(CRG,Barcelona Institute of Science and Technology(BIST),08028,Barcelona,Spain [4]Centro Nacional de Biotecnología,CSIC,28049,Madrid,Spain [5]Division of Microbiology and Immunology,Yerkes National Primate Research Center,Emory University,Atlanta,GA,USA [6]Department of Pathology and Laboratory Medicine,School of Medicine,Emory University,Atlanta,Georgia,USA [7]Division of Pathology,Yerkes National Primate Research Center,Emory University,Atlanta,Georgia,USA [8]Germans Trias i Pujol Research Institute(IGTP),Can Ruti Campus,089,Badalona,Spain [9]Barcelona Supercomputing Center(BSC),08034,Barcelona,Spain [10]Catalan Institution for Research and Advanced Studies(ICREA),08010,Barcelona,Spain [11]University of Vic-Central University of Catalonia(UVic-UCC),Vic,08500,Spain [12]Department of Integrative Structural and Computational Biology,Scripps Research,La Jolla,CA,92037,USA [13]Universitat Pompeu Fabra(UPF),Barcelona,Spain [14]UAB,CReSA(IRTA-UAB),Campus de la UAB,08193,Bellaterra(Cerdanyola del Vallès),Spain [15]Departament de Sanitat i Anatomia Animals,Facultat de Veterinària,UAB,08193,Bellaterra(Cerdanyola del Vallès),Spain

出　　处：《Cellular & Molecular Immunology》2021年第12期2676-2678,共3页中国免疫学杂志（英文版）

基　　金：The authors also acknowledge the crowdfunding initiative#Yomecorono(https://www.yomecorono.com).N.I.-U.is supported by the grant PID2020-117145RB-I00 from the Spanish Ministry of Science and Innovation;J.M.-P.is supported by the grant PID2019-109870RB-I00 from the Spanish Ministry of Science and Innovation and in part also by Grifols.The C.R.laboratory is funded by RTI2018-094445-B100(MCIU/AEI/FEDER,UE);The NHP study was primarily supported by a YNPRC Coronavirus Pilot Research Project Program grant to M.Pa.under award P51 OD11132,Emergent Venture Fast grant program to M.Pa.under awards#2206 and#2144,and William and Lula Pitts Foundation(to M.Pa.);X.M.-T.is supported by the Spanish Ministry of Science and Innovation and the European Regional Development Fund under agreement BES-2017-082900.The funders had no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.

摘　　要：Antigen-presenting cells(APCs)may be resistant to SARS-CoV-2 infection but still contribute to viral pathogenesis.Lectins such as sialic acid-binding Ig-like lectin 1(Siglec-1/CD169)mediate the attachment of viruses to APCs.Here,we show that APCs effectively capture SARS-CoV-2 within compartments via recognition of Siglec-1.This receptor interacts with sialylated gangliosides on membranes of SARS-CoV-2 variants.

关 键 词：INFECTION ANTIGEN media 

分 类 号：R563.1[医药卫生—呼吸系统]