TIMP-2基因-418G/C多态性与房颤性脑梗死的关系研究  

Association between matrix metalloproteinase inhibitor-2 gene-418G/C polymorphisms and cerebral infarction with atrial fibrillation

作　　者：李卫玲[1] 金笑平[1] 虞丹[1] 沈玉光 LI Wei-ling;JIN Xiao-ping;YU Dan;SHEN Yu-guang(Department of Neurology,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai,Zhejiang 317000,China)

机构地区：[1]浙江省台州医院神经内科,浙江临海317000

出　　处：《中华全科医学》2022年第3期411-414,共4页Chinese Journal of General Practice

基　　金：浙江省基础公益研究项目(LGF18H090019);浙江省医药卫生科技计划项目(2020KY1035)。

摘　　要：目的心房颤动引起的梗死是目前缺血性卒中患者高死亡率的主要原因之一,基于基质金属蛋白酶抑制因子(TIMP)在房颤心肌维化过程中重要作用,本文探讨了TIMP-2基因启动子-418G/C多态性与房颤引起脑梗死的关系。方法采用聚合酶链反应-限制性片段长多态性法对2016年1月—2018年6月浙江省台州医院神经内科首次因房颤性脑梗死住院患者204例(观察组)及非心源性脑梗死248例(对照组)进行TIMP-2基因启动子区-418G/C多态性检测,并对2组患者的一般情况及基因型、等位基因等进行比较。结果观察组和对照组性别、年龄、吸烟、饮酒、入院时收缩压及舒张压、空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、纤维蛋白原、同型半胱氨酸等差异均无统计学意义(均P>0.05)。观察组GC+CC基因型共94例(46.1%),对照组GC+CC基因型共90例(36.3%),2组比较差异有统计学意义(P=0.043,95%CI:1.017~1.585),观察组C等位基因115例(28.2%),与对照组[106例(21.4%)]比较差异有统计学意义(P=0.020,95%CI:1.049~1.658)。结论TIMP-2基因-418G/C位点多态性与房颤性脑梗死遗传易感性可能相关。Objective Cerebral infarction caused by atrial fibrillation is a principal cause of high mortality in patients with ischaemic stroke.Considering the important role of matrix metalloproteinase inhibitor(TIMP)in the myocardial dimension process of atrial fibrillation,this study investigates the relationship between promoter region polymorphism(-418G/C)of TIMP-2 and cerebral infarction caused by atrial fibrillation.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was used to detect TIMP-2 gene promoter region-418G/C site polymorphism in 204 cases of cerebral infarction of atrial fibrillation(case group)and 248 cases of noncardiogenic cerebral infarction(control group)with first admission between January 2016 and June 2018.The general,genotype and all of the groups were compared.Results No significant differences in gender,age,tobacco and alcohol habits,systolic and diastolic blood pressure at admission,fasting glucose,triglyceride,total cholesterol,low-density lipoprotein cholesterol,fibrinogen and homocysteine were found between the case and control groups(all P>0.05).A total of 94 cases of the case group in GC+CC genotype accounted for 46.1%,and 90 cases of the control group in GC+CC genotype accounted for 36.3%;the difference between the two groups was statistically significant(P=0.043,95%CI:1.017-1.585).On the time,there were 115 cases of the case group in C allele,accounting for 28.2%,while 106 cases of the control group,accounting for 21.4%.The difference between the two groups was statistically significant(P=0.020,95%CI:1.049-1.658).Conclusion The TIMP-2(-418gG/C)polymorphism may be associated with genetic susceptibility in cerebral infarction with atrial fibrillation.

关 键 词：基质金属蛋白酶抑制因子-2 房颤 脑梗死 基因多态性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]