阴道微生态与HPV感染及宫颈病变的关系探讨  

Discussion on the relationship between vaginal microecology and HPV infection,cervical lesions

作　　者：郭凤 黄伟[1] 王佩红[1] 赵莉[1] GUO Feng;HUANG Wei;WANG Peihong;ZHAO Li(Gynaecology Department,Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院妇科,陕西汉中723000

出　　处：《临床医学研究与实践》2022年第9期17-20,共4页Clinical Research and Practice

基　　金：汉中市中心医院院级科研基金项目(No.Yk17020)。

摘　　要：目的探讨阴道微生态与人乳头瘤病毒(HPV)感染及宫颈病变的关系。方法选择于我院接受宫颈病变筛查的240例女性为研究对象,分析受检者的阴道pH、乳酸杆菌减少、细菌性阴道炎(BV)、滴虫性阴道炎(TV)、念珠菌性阴道炎(VVC)等阴道微生态变化异常率,HPV感染率及感染类型,宫颈病变异常及病变类型。分析阴道微生态指标与HPV感染及宫颈病变的关系。结果筛查的240例女性中,62例HPV+,其中低危20例、高危42例。HPV+受检者的乳酸杆菌减少、BV发生率高于HPV-受检者,差异具有统计学意义(P<0.05)。HPV低危和高危感染者的乳酸杆菌减少、BV发生率高于HPV-受检者,差异具有统计学意义(P<0.05)。筛查的240例女性中,宫颈异常35例,其中LSIL 25例、HSIL 7例、宫颈癌3例。宫颈异常受检者的pH异常、乳酸杆菌减少、BV发生率高于宫颈炎/正常受检者,差异具有统计学意义(P<0.05)。HSIL+宫颈癌和LSIL受检者的pH异常、乳酸杆菌减少、BV发生率高于宫颈炎/正常受检者,差异具有统计学意义(P<0.05)。宫颈异常者的HPV+发生率高于宫颈炎/正常者,差异具有统计学意义(P<0.05);宫颈异常者的HPV低危和高危感染率高于宫颈炎/正常者,差异具有统计学意义(P<0.05)。在宫颈异常者中,LSIL和HSIL+宫颈癌者的HPV+发生率高于宫颈炎/正常者,差异具有统计学意义(P<0.05);LSIL和HSIL+宫颈癌者的HPV低危和高危感染率高于宫颈炎/正常者,差异具有统计学意义(P<0.05)。结论阴道微生态失调可增加机体HPV感染率以及宫颈病变风险,临床上应重视阴道微生态的检查,加强HPV感染监测及宫颈病变筛查。Objective To explore the relationship between vaginal microecology and human papilloma virus(HPV)infection,cervical lesions.Methods A total of 240 women who received cervical lesions screening in our hospital were selected as the research objects.The abnormal rates of vaginal pH,Lactobacillus reduction,bacterial vaginitis(BV),trichomonal vaginitis(TV),vulvovaginal candidiasis(VVC)and other vaginal microecological changes,HPV infection rate and infection type,abnormal cervical lesions and lesion type were analyzed.The relationship between vaginal microecological indexes and HPV infection,cervical lesions were analyzed.Results Among the 240 screened women,there were 62 cases of HPV+,including 20 cases low-risk and 42 cases high-risk.The incidences of Lactobacillus reduction and BV in HPV+objects were higher than those in HPV-objects,and the differences were statistically significant(P<0.05).The incidences of Lactobacillus reduction and BV in objects with low-risk and high-risk HPV infection were higher than those in HPV-objects,and the differences were statistically significant(P<0.05).Among the 240 screened women,there were 35 cases of cervical abnormalities,including 25 cases of LSIL,7 cases of HSIL and 3 cases of cervical cancer.The incidences of abnormal pH,Lactobacillus reduction and BV in objects with cervical abnormalities were higher than those in cervicitis/normal objects,and the differences were statistically significant(P<0.05).The incidences of abnormal pH,Lactobacillus reduction and BV in HSIL+cervical cancer and LSIL objects were higher than those in cervicitis/normal objects,and the differences were statistically significant(P<0.05).The incidence of HPV+in objects with cervical abnormalities was higher than that in cervicitis/normal objects,and the differences were statistically significant(P<0.05);the low-risk and high-risk HPV infection rates in objects with cervical abnormalities were higher than those in cervicitis/normal objects,and the differences were statistically significant(P<0.05).In objec

关 键 词：阴道微生态 HPV感染 宫颈病变 

分 类 号：R737.33[医药卫生—肿瘤]