血清基质金属蛋白酶-10、血管内皮生长因子水平与胆囊癌手术患者临床预后的关系  

Relationship Between Serum Matrix Metalloproteinase-10,Vascular Endothelial Growth Factor Levels and Clinical Prognosis of Patients with Gallbladder Cancer Surgery

作　　者：李新民 LI Xinmin(Department of General Surgery,Shangqiu Fifth People’s Hospital,Shangqiu 476000,China)

机构地区：[1]商丘市第五人民医院普外科,河南商丘476000

出　　处：《河南医学研究》2022年第5期837-840,共4页Henan Medical Research

摘　　要：目的观察血清基质金属蛋白酶-10(MMP-10)、血管内皮生长因子(VEGF)在胆囊癌手术患者中的表达,并分析二者与患者临床预后的关系。方法选择2019年7月至2020年7月商丘市第五人民医院收治的160例胆囊癌患者,均在医院接受胆囊癌根治术治疗。术后随访1a,记录患者生存情况,将病死患者纳入预后不良组,将存活患者纳入预后良好组;所有患者入院时均接受血清MMP-10、VEGF水平检测,询问并记录两组患者基线资料;重点分析血清MMP-10、VEGF水平与胆囊癌手术患者临床预后的关系。结果经1a随访,160例胆囊癌手术患者中,存活114例(71.25%),病死46例(28.75%);预后不良组中、低分化患者占比高于预后良好组,入院时血清MMP-10、VEGF水平高于预后良好组(P<0.05);cox回归分析结果显示,血清MM-P、VEGF过表达与胆囊癌手术患者预后不良有关(OR>1,P<0.05);绘制受试者工作特征(ROC)曲线,结果显示,血清MMP-10、VEGF水平单独及联合预测胆囊癌手术患者预后不良的ROC曲线下面积(AUC)均>0.70,有一定预测价值,其中联合检测价值最高。结论血清MMP-10、VEGF过表达与胆囊癌手术患者临床预后不良有一定联系。Objective To observe the expression of serum matrix metalloproteinase-10(MMP-10)and vascular endothelial growth factor(VEGF)in patients with gallbladder cancer surgery,and to analyze the relationship between the two and clinical prognosis of patients.Methods A total of 160 patients with gallbladder cancer treated in Shangqiu Fifth People’s Hospital from July 2019 to July 2020 were selected,and all patients were treated with radical cholecystectomy in hospital.The survival condition of patients was recorded at 1 year of follow-up after operation.The dead patients were included in the poor prognosis group,and the surviving patients were included in the good prognosis group.All patients received detection of serum MMP-10 and VEGF levels at admission,then the baseline data of patients in the two groups were asked and recorded.The relationship between the levels of serum MMP-10 and VEGF and the clinical prognosis of patients with gallbladder cancer surgery were mainly analyzed.Results After one year of follow-up,114 cases(71.25%)survived and 46 cases(28.75%)died.The proportion of middle and poorly differentiated patients in the poor prognosis group was higher than that in the good prognosis group,and the levels of serum MMP-10 and VEGF at admission were higher than those in the good prognosis group(P<0.05).Cox regression analysis showed that,the overexpression of serum MMP-10 and VEGF was related to the poor prognosis of patients with gallbladder cancer surgery(OR>1,P<0.05).The receiver operating characteristic(ROC)curve was drawn,and the results showed that,the area under ROC curve(AUC)of serum MMP-10 and VEGF alone and combined to predict the poor prognosis of patients with gallbladder cancer surgery were all>0.70,which had a certain prediction value,among which the joint detection value was the highest.Conclusion The overexpression of serum MMP-10 and VEGF are related to the poor clinical prognosis of patients with gallbladder cancer surgery.

关 键 词：胆囊癌 胆囊癌根治术 基质金属蛋白酶-10 血管内皮生长因子 预后 

分 类 号：R735.8[医药卫生—肿瘤]