循环血VEGF和MIC-1的表达与非小细胞肺癌临床病理特征及预后的关系分析  

Analysis of the Relationship Between the Expression Levels of Circulating Blood VEGF and MIC-1 and the Pathological Characteristics and Prognosis of Non-small Cell Lung Cancer

作　　者：孙娟子 孙苏娟 宋舒曼 白娇红 SUN Juanzi;SUN Sujuan;SONG Shuman(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000 [2]河南省洛阳市妇幼保健院,471099

出　　处：《实用癌症杂志》2022年第3期355-357,共3页The Practical Journal of Cancer

基　　金：河南省科技计划项目(编号:152102310406)。

摘　　要：目的探讨循环血VEGF和MIC-1的表达与非小细胞肺癌临床病理特征及预后的关系。方法采用ELISA检测了100例健康体检者(对照组)及156例NSCLC患者的VEGF和MIC-1水平,分析其与患者临床病理特征及预后的关系。结果研究组患者VEGF和MIC-1水平均显著高于对照组(P<0.05);研究组中不同病理类型患者VEGF和MIC-1水平比较无差异(P>0.05);研究组中随着患者病理分期的不断升高,VEGF和MIC-1水平亦逐渐升高(P<0.05);存活时间≤1年的VEGF和MIC-1高水平患者占比明显高于存活时间>1年的患者(P<0.05)。结论VEGF和MIC-1两指标可较好的作为NSCLC的筛查、病情进展评估的血液指标,此与病理检查联合应用可对NSCLC的预后改善提供帮助。Objective To investigate the relationship between the expression levels of circulating blood VEGF and MIC-1 and the pathological characteristics and prognosis of non-small cell lung cancer.Methods The levels of VEGF and MIC-1 in 100 healthy physical examiners(control group)and 156 patients with NSCLC were detected by ELISA,the relationship of pathological characteristics and prognosis were analyzed.Results The levels of VEGF and MIC-1 indicators were significantly higher in the study group than in the control group(P<0.05);There was no difference in the levels of VEGF and MIC-1 indicators among patients with different pathological subtypes in the study group(P>0.05);The levels of VEGF and MIC-1 indicators gradually increased with the increasing pathological stage of patients in the study group(P<0.05).The proportion of patients with high levels of VEGF and MIC-1 with survival time≤1 year was significantly higher than that of patients with survival time>1 year(P<0.05).Conclusion VEGF and MIC-1 can be better used as blood indicators for screening and progression assessment of NSCLC,and their combined application with pathological examination can help to improve the prognosis of NSCLC.

关 键 词：非小细胞肺癌 血管内皮生长因子 巨噬细胞抑制因子-1 病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]