火针对寒凝血瘀型原发性痛经患者PGF_(2α)、PGE_(2)水平的影响及临床效果  

Study on the Regulation Mechanism of Fire on PGF_(2α) and PGE_(2) in Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

作　　者：曾少君 郑敏钦 翁财 ZENG Shao-jun;ZHEN Min-qin;WENG Cai(Fujian University of Traditional Chinese Medicine,FuZhou,350001;Fuzhou hospital of traditional Chinese medicine,FuZhou350013;The Second A affiliated Hospital of Fujian traditional Chinese Medicine University,FuZhou,350001)

机构地区：[1]福州市中医院,福建福州350013 [2]福建中医药大学,福建福州350001 [3]福建中医药大学附属第二人民医院,福建福州350001

出　　处：《按摩与康复医学》2022年第9期5-8,共4页Chinese Manipulation and Rehabilitation Medicine

基　　金：福州市科技计划项目(2019-SZ-36);福建省教育厅JAT200206。

摘　　要：目的:探究火针对寒凝血瘀型原发性痛经患者PGF_(2α)、PGE_(2)的影响及临床效果。方法:把符合纳入标准的90例寒凝血瘀型原发性痛经患者随机分成三组,每组30例,火针组采用火针针刺十七椎、三阴交(双侧)、关元、气海、次髎(双侧),药物组采用内服西药,针刺组采用普通针针刺十七椎、三阴交(双侧)、关元、气海、次髎(双侧)。结果:火针组总有效率(96.7%)优于针刺组(86.7%)和西药组(83.3%)(P<0.05);三组治疗前后PGF_(2α)、PGE_(2)含量比较差异均有统计学意义(P<0.05),治疗后三组PGF_(2α)含量均有不同程度地降低、PGE_(2)含量均有不同程度地升高,但火针组明显优于针刺组和西药组(P<0.05)。结论:火针治疗寒凝血瘀型原发性痛经的临床疗效显著,其疗效机制与经期外周血中PGF_(2α)、PGE_(2)水平变化密切相关,可能是通过降低外周血中PGF_(2α)、升高PGE_(2)水平发挥止痛作用。Objective:To explore the mechanism of fire regulating PGF_(2α) and PGE_(2) in primary dysmenorrhea with cold coagulation and blood stasis.Methods:90 patients with primary dysmenorrhea hemorheological nature blood stasis syndrome were divided themselves into three groups according to random number,30 cases in each group,using fire needle acupuncture seventeen vertebral,three Yin fire needle group(bilateral),guan yuan,qi hai,time liao(bilateral),drug group USES the internal and the western medicine,acupuncture group with common acupuncture seventeen vertebral,three vaginal intercourse(both sides),guan yuan,qi hai,liao(double side).Results:The total effective rate of acupuncture group(96.7%)was better than that of acupuncture group(86.7%)and western medicine group(83.3%)(P<0.05).The contents of PGF_(2α) and PGE_(2) in the three groups were significantly different before and after treatment(P<0.05).After treatment,the contents of PGF_(2α) and PGE_(2) in the three groups were decreased to vary‐ing degrees,while the contents of PGE_(2) were increased to varying degrees.However,the fire acupuncture group was significantly better than the acu‐puncture group and the western medicine group(P<0.05). Conclusion:The therapeutic effect of fire acupuncture on primary dysmenorrhea of cold coagulation and blood stasis type is significant.The mechanism of therapeutic effect is closely related to the changes of PGF_(2α) and PGE_(2) levels in pe‐ripheral blood during menstruation,which may play an analgesic role by decreasing PGF_(2α) and increasing PGE_(2) levels in peripheral blood.

关 键 词：火针 原发性痛经 PGF2Α PGE2 

分 类 号：R245.3[医药卫生—针灸推拿学]