EMT在结肠癌干细胞“干性”获得与维持中的作用及机制研究进展  

Research advancement on the role and mechanism of epithelial mesenchymal transition in the acquisition and maintenance of colon cancer stem cell "stemness"

作　　者：康毅 周晏因(综述) 朱蓉(审校) KANG Yi;ZHOU Yan-yin;ZHU Rong(Department of Gastroenterology,the Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,CHINA)

机构地区：[1]遵义医科大学附属医院消化内科,贵州遵义563000

出　　处：《海南医学》2022年第6期782-786,共5页Hainan Medical Journal

基　　金：贵州省科学技术基金项目(编号:黔科合LH字[2014]7573号);遵义医科大学附属医院院基金项目(编号:院字[2016]45号)。

摘　　要：结肠癌是消化道常见的恶性肿瘤,在全球其发病率高居第三。大部分结肠癌患者的死亡由肿瘤的复发、转移和耐药性所导致,而这些过程都有结肠癌干细胞(CCSCs)的介入。上皮间充质转化(EMT)在胚胎发育、肿瘤发生及其浸润转移等过程中都起着重要的调节作用。近来研究发现,EMT与CCSCs之间存在重要的相互联系,CCSCs的“干性”获得与维持与EMT密切相关,同时CCSCs在不同的微环境又具有EMT特性,从而在肿瘤的产生、进展和转移过程中发挥着十分重要的作用。本文总结国内外关于CCSCs和肿瘤细胞EMT关系的研究进展,阐明CCSCs与EMT的相互关系及其调控机制,以期为其靶向治疗找到新途径。Colon cancer is a common malignant tumor of the digestive tract, with the third highest morbidity in the world. Most of the deaths of patients with colon cancer are caused by tumor recurrence and metastasis and drug resistance, and these processes involve colon cancer stem cells(CCSCs). Epithelial mesenchymal transition(EMT) plays an important role in regulating embryonic development, tumorigenesis, infiltration and metastasis. Recent studies have found that there is an important correlation between EMT and CCSCs. The acquisition and maintenance of "stemness" of CCSCs is closely related to EMT. At the same time, CCSCs has EMT characteristics in different microenvironments,thus playing a very important role in the process of tumor generation, progression and metastasis. This article summarizes the research progress on the relationship between CCSCs and tumor cell EMT at home and abroad, and clarifies the relationship between CCSCs and EMT and its regulatory mechanism, in order to find a new way for its targeted therapy.

关 键 词：结肠癌干细胞 上皮间充质转化 结肠癌 机制 靶向治疗 研究进展 

分 类 号：R735.35[医药卫生—肿瘤]