血清肿瘤标志物联合检测在原发性肝癌诊断中的应用价值  

Application of Combined Detection of Serum Tumor Markers in the Diagnosis of Primary Liver Cancer

作　　者：张梅儒 赵琳[1] 王志霞 刘婷婷 万芳[1] ZHANG Meiru;ZHAO Lin;WANG zhixia;LIU Tingting;WAN Fang(Gansu Baiyin First People's Hospital,Baiyin 730900,China)

机构地区：[1]甘肃白银市第一人民医院,甘肃白银730900

出　　处：《中国医药指南》2022年第10期101-103,共3页Guide of China Medicine

摘　　要：目的探讨血清肿瘤标志物甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)、癌胚抗原(CEA)、癌抗原199(CA199)联合检测在原发性肝癌诊断中的应用价值。方法选择医院2018年6月至2019年6月收治的100例原发性肝癌患者(原发性肝癌组)作为本次研究入组对象,同时纳入100例良性肝脏疾病患者(良性肝病组)以及同时期100名健康体检的志愿者(健康组)作为对照,对比3组患者的血清肿瘤标志物检测结果。结果肝癌组AFP、AFU、CEA、CA199高于良性肝病组和健康组(P<0.05);良性肝病组AFU、CA199高于与健康组(P<0.05)。未分化和低分化患者血清肿瘤标志物水平显著高于高分化和中分化的原发性肝癌患者,差异有统计学意义(P<0.05);原发性肝癌转移组的血清标志物高于未发生肿瘤转移组(P<0.05)。HBV感染与未感染血清肿瘤标志物水平比较,差异无统计学意义(P>0.05)。血清肿瘤标志物AFP+AFU、AFP+AFU+CEA、AFP+AFU+CEA+CA199联合检测的敏感性、准确性与单一检测相比均显著提高(P<0.05),其中4项联合检测的敏感性为90.00%、准确性为89.00%。结论血清肿瘤标志物联合检测在原发性肝癌诊断中的应用有助于提高原发性肝癌诊断的敏感性和准确性。Objective To investigate the serum tumor markers alpha fetoprotein(AFP)α-L-Fucosidase(AFU)Application of combined detection of carcinoembryonic antigen(CEA)and carcinoembryonic antigen 199(CA199)in the diagnosis of primary liver cancer.Methods A total of 100 patients with primary liver cancer treated in our hospital from June 2018 to June 2019 were selected as the subjects of this study(primary liver cancer group),and 100 patients with benign liver diseases(benign liver disease group)and volunteers undergoing physical examination(healthy group)at the same time were included as the control.The detection results of serum tumor markers of the three groups were compared.Results The levels of AFP,AFU,CEA and CA199 in liver cancer group were higher than those in benign group and healthy group(P<0.05).AFU and CA199 in benign group were higher than those in healthy group(P<0.05).The levels of serum tumor markers in undifferentiated and poorly differentiated patients were significantly higher than those in highly and moderately differentiated patients with primary liver cancer(P<0.05).The serum markers in primary liver cancer metastasis group were higher than those in non metastasis group(P<0.05).There was no difference between HBV infected and uninfected serum tumor markers(P>0.05).The sensitivity and accuracy of combined detection of serum tumor markers AFP+AFU,AFP+AFU+CEA and AFP+AFU+CEA+CA199 were significantly higher than those of each(P<0.05).The sensitivity and accuracy of four combined detection were 90.00%and 89.00%.Conclusion The application of combined detection of serum tumor markers in the diagnosis of primary liver cancer is helpful to improve the sensitivity and accuracy of the diagnosis of primary liver cancer.

关 键 词：原发性肝癌 血清肿瘤标志物 联合检测 诊断价值 

分 类 号：R730.3[医药卫生—肿瘤]