Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities  

作　　者：ZHONG Xiang-Jian ZHOU Na WANG Xin LI Jin-Jie MA Hui JIAO Yue XU Jia-Hui LIN Peng-Cheng SHANG Xiao-Ya 

机构地区：[1]Beijing Key Laboratory of Bioactive Substances and Functional Foods,Beijing Union University,Beijing 100191,China [2]Shandong Institute for Product Quality Inspection,Jinan 250100,China [3]Key Laboratory for Qinghai-Tibet Plateau Phytochemistry of Qinghai Province,Qinghai Nationalities University,Xining 810000,China

出　　处：《Chinese Journal of Natural Medicines》2022年第2期155-160,共6页中国天然药物（英文版）

基　　金：supported by the Key Projects of Beijing Natural Sciences Foundation and Beijing Municipal Education Committee(No.KZ201811417049);the Scientific Research Common Program of Beijing Municipal Commission of Education(No.KM202011417014);the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(No.2019-ZJ-Y19);Beijing Union University Graduate Research and Innovation Fund Project(No.YZ2020K001);the Academic Research Projects of Beijing Union University(No.XP202005)。

摘　　要：Three new ursane-type triterpenoids,3-oxours-12-en-20,28-olide(1),3β-hydroxyurs-12-en-20,28-olide(2)and 3β-hydroxyurs-11,13(18)-dien-20,28-olide(3),were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis.Their structures were elucidated by a combination of extensive 1D-and 2D-NMR experiments,MS data and comparisons with literature reports.Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages,but no antibacterial activity was found at a concentration of 128μg·mL^(-1).

关 键 词：Rosmarinus officinalis Isolation and purification TRITERPENOID Biological activity 

分 类 号：R284.1[医药卫生—中药学]