利奈唑胺的波谱学特征和结构确证  

Spectroscopic Characteristics and Structure Identification of Linezolid

作　　者：黄进 葛永红[2] 朱琳 袁磊 罗玉全 高浩凌 HUANG Jin;GE Yong-hong;ZHU lin;YUAN Lei;LUO Yu-quan;GAO Hao-ling(Changhai Biological Company,Zhejiang Medicine Co.,Ltd.,Shaoxing,Zhejiang 312300,China;Xinchang Pharmaceutical Factory,Zhejiang Medicine Co.,Ltd.,Shaoxing,Zhejiang 312500,China;Research&Development Center,Zhejiang Medicine Co.,Ltd.,Shaoxing,Zhejiang 312300,China)

机构地区：[1]浙江医药股份有限公司昌海生物分公司,浙江绍兴312300 [2]浙江医药股份有限公司新昌制药厂,浙江绍兴312500 [3]浙江医药股份有限公司研究院,浙江绍兴312300

出　　处：《浙江化工》2022年第3期49-54,共6页Zhejiang Chemical Industry

摘　　要：目的:确定利奈唑胺的化学结构。方法:通过紫外光谱(UV)、红外光谱(IR)、高分辨质谱(HRMS)、核磁共振谱、热分析(TGA/DSC)、粉末X-射线(PXRD)对利奈唑胺进行结构表征。结果:对UV、HRMS、NMR检测结果进行解析和归属,确定了样品的分子结构;通过IR、TGA/DSC和PXRD的检测结果分析,确定了样品为晶型Ⅱ。结论:综合运用多种谱学方法确证了利奈唑胺的结构,为其质量研究提供参考依据。Objective:To determine the chemical structure of linezolid.Methods:The structure of linezolid was characterized by ultraviolet spectroscopy(UV),infrared spectroscopy(IR),high resolution mass spectrometry(HRMS),nuclear magnetic resonance spectroscopy,thermal analysis(TGA/DSC)and powder X-ray(PXRD).Results:The molecular structure of the sample was determined by analyzing and assigning the detection results of UV,HRMS and NMR.The sample was confirmed to be crystal formⅡby analyzing the detection results of IR,TGA/DSC and PXRD.Conclusion:The structure of linezolid was confirmed by comprehensive use of multiple spectroscopic methods,which provided a reference for its quality research.

关 键 词：利奈唑胺 波谱特征 核磁共振 晶型 结构确证 

分 类 号：TQ465[化学工程—制药化工] O652[理学—分析化学]