乳腺浸润性导管癌SLeX和Maspin表达的临床病理研究  

Clinicopathologic Study on Expression of SLeX and Maspin in Invasive Ductal Carcinoma Tissue of Breast

作　　者：张伟[1] 乔树平 尚培中[1] 刘冰[1] 李伟[3] 南润玲 ZHANG Wei;QIAO Shu-ping;SHANG Pei-zhong;LIU Bing;LI Wei;NAN Run-ling(Department of General Surgery,The 81 Group Army Hospital of PLA,Zhangjiakou,Hebei 075000,China;Department of General Surgery,Shiji Hospital of Huailai,Huailai,Hebei 075400,China;Department of Pathologicaland Medical Laboratory,The 81 Group Army Hospital of PLA,Zhangjiakou,Hebei 075000,China)

机构地区：[1]中国人民解放军陆军第八十一集团军医院普通外科,河北张家口075000 [2]河北怀来世济医院普通外科,河北怀来075400 [3]中国人民解放军陆军第八十一集团军医院检验病理科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2022年第6期1-5,8,共6页Journal of Hebei North University:Natural Science Edition

基　　金：张家口市大健康和生物医疗专项重点研发计划项目(No.2021064D)。

摘　　要：目的探讨SLeX和Maspin表达与乳腺浸润性导管癌(BIDC)临床病理指标及预后的关系。方法80例BIDC手术切除标本及30例距癌灶3 cm的癌旁乳腺组织,应用EliVision^(TM) plus免疫组织化学二步法检测SLeX和Maspin在癌组织及癌旁乳腺组织中的表达,分析SLeX和Maspin与病人年龄、TNM分期、分化等级、淋巴结宏转移、术后5年内复发转移等临床病理指标的相关性。结果癌组织SLeX和Maspin阳性率分别为86.3%(69/80)和47.5%(38/80),癌旁乳腺组织分别为20.0%(6/30)和93.3%(28/30),差异有统计学意义(均P<0.05)。SLeX和Maspin表达与年龄无关(均P>0.05)。在TNM(T3+T4)期、低分化、有淋巴结宏转移和5年内复发转移病人中SLeX高表达,Maspin低表达,呈负相关(r=-0.33)。结论SLeX和Maspin与BIDC发生发展显著相关,SLeX表达上调或(和)Maspin表达下调均预示癌组织分化差、进展快、预后不良。Objective To investigate the SLeX and Maspin expression in breast invasive ductal carcinoma(BIDC)and the relationship with clinicopathologic parameters and prognosis.Methods A retrospective study of 80 continuous patients with BIDC who underwent resection was conducted.The expression of SLeX and Maspin in 80 BIDC tissues and 30 paracancerous tissues were detected by EliVision^(TM) plus two-step immunohistochemical method.The relationships between the expressions of SLeX and Maspin and the clinicopathologic parameters including patient age,TNM staging,differentiated degree,lymph node macrometastasis,recurrence and metastasis 5 years after surgery were studied.Results The positive rates of SLeX and Maspin were 86.3%and 47.5%for cancer tissues and 20.0%and 93.3%for paracancerous tissues,respectively,with statistically significant differences(P<0.05).There was no significant difference in the expressions of SLeX and Maspin between the age of two groups(P>0.05).In patients with high TNM stage(T3 and T4),poor differentiation,lymph node macrometastasis,and recurrence and metastasis within 5 years of follow-up,SLeX was highly expressed,but Maspin was low expressed.A significant inverse relationship was observed between the expressions of SLeX and Maspin in BIDC tissue(r=-0.33).Conclusion Both expressions of SLeX and Maspin may take part in the progress of BIDC.The up-regulated SLeX expression and the down-regulated Maspin expression may hint poor differentiation,rapid progress and poor prognosis of carcinoma tissue.

关 键 词：癌 导管 乳腺 SLEX MASPIN 肿瘤浸润 肿瘤转移 预后 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]