Measurement of crystalline lens tilt in high myopic eyes before cataract surgery using swept-source optical coherence tomography  

作　　者：Qiang Lu Wenwen He Dongjin Qian Yi Lu Xiangjia Zhu 

机构地区：[1]Department of Ophthalmology,Eye and Ear,Nose,and Throat Hospital,Fudan University,83 Fenyang Road,Shanghai 200031,People’s Republic of China [2]Eye Institute,Eye and Ear,Nose,and Throat Hospital of Fudan University,Shanghai 200031,People’s Republic of China [3]Key Laboratory of Myopia,Ministry of Health,Shanghai 200031,People’s Republic of China [4]Shanghai Key Laboratory of Visual Impairment and Restoration,Shanghai 200031,People’s Republic of China

出　　处：《Eye and Vision》2020年第1期128-135,共8页眼视光学杂志（英文）

基　　金：This research was funded by research grants from the National Natural Science Foundation of China(81870642,81970780,81470613,81100653,81670835,and 81270989);the National Key R&D Program of China(2018YFC0116800);the Shanghai Talent Development Fund(201604);the Shanghai Youth Doctor Support Program(2014118);the Outstanding Youth Medical Talents Program of the Shanghai Health and Family Planning Commission(2017YQ011).

摘　　要：Background:To measure the crystalline lens tilt in eyes with various degrees of myopia before cataract surgery using swept-source optical coherence tomography(SS-OCT).Methods:We used SS-OCT(IOLMaster 700)to scan 131 emmetropic eyes(axial length<24.5 mm),25 mild/moderate myopic eyes(axial length 24.5–26 mm),and 123 high myopic eyes(52,29,and 42 eyes with axial lengths of 26–28,28–30,and>30 mm,respectively)as part of the routine preoperative examination before cataract surgery.SS-OCT involved B-scans along six meridians.The data were analyzed to assess the magnitude and orientation of the lens tilt and their correlation with other optical biometric parameters.Result:The mean tilt was 3.36±0.98°in emmetropic eyes,3.07±1.04°in mild/medium myopic eyes,and 2.35±1.01°in high myopic eyes.Tilt correlated significantly and inversely with axial length(Pearson’s r=−0.427,P<0.001).The crystalline lens tilt predominantly faced the upper outer quadrant relative to the visual axis,symmetrically in both eyes,with mean angles of 24.32°and 147.36°in the right and left eyes,respectively.The variability in the lens tilt direction increased with increasing axial length(χ^(2) test,P<0.001).Conclusion:The magnitude of crystalline lens tilt decreased with increasing axial length.The direction of tilt was predominantly towards the upper outer quadrant in both eyes.The variability in the tilt orientation increased with increasing axial length.Trial registration:NIH(clinicaltrial.gov),NCT03062085.Registered 23 February 2017.

关 键 词：Crystalline lens tilt ORIENTATION MAGNITUDE High myopia Swept-source optical coherence tomography 

分 类 号：R779.6[医药卫生—眼科] R770.43[医药卫生—临床医学]