Artificial neural network to guide intracorneal ring segments implantation for keratoconus treatment:a pilot study  

作　　者：Chiara Fariselli Alfredo Vega-Estrada Francisco Arnalich-Montiel Jorge L.Alio 

机构地区：[1]Research and Development Department,Vissum,Calle Cabañal,1.Edificio Vissum,03016 Alicante,Spain [2]Department of Experimental,Diagnostic,and Specialty Medicine(DIMES),Ophthalmology Service,St.Orsola-Malpighi Teaching Hospital,University of Bologna,Bologna,Italy [3]Cornea and Refractive Surgery Department,Vissum,Alicante,Spain [4]Division of Ophthalmology,Universidad Miguel Hernández,Alicante,Spain [5]Cornea and Refractive Surgery Department,Vissum,Madrid,Spain

出　　处：《Eye and Vision》2020年第1期189-200,共12页眼视光学杂志（英文）

摘　　要：Background:To analyze the clinical results of an artificial neural network(ANN)that has been processed in order to improve the predictability of intracorneal ring segments(ICRS)implantation in keratoconus.Methods:This retrospective,comparative,nonrandomized,pilot,clinical study included a cohort of 20 keratoconic eyes implanted with intracorneal ring segments KeraRing(Mediphacos,Belo Horizonte,Brazil)using the ANN(ANN group)and 20 keratoconic eyes implanted with KeraRing using the manufacturer’s nomograms(nomogram group).Uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA)(visual acuity is expressed in decimal value and in LogMAR value in brackets),manifest refraction,corneal topography,tomography,aberrometry,pachymetry and volume analysis(Sirius System.CSO,Firenze,Italy)were performed during the preoperative visit;and the two groups,ANN group and nomogram group,did not differ significantly preoperatively in all of the parameters evaluated.These preoperative values were compared with the results obtained at the third-month visit.Mann-Whitney test and Wilcoxon test were used for the statistical analyses.Results:The spherical equivalent and the keratometric values decreased significantly in both groups.The CDVA improved from 0.60±0.23(0.22 LogMAR)pre-operatively to 0.73±0.21(0.14 LogMAR)post-operatively in the ANN group(p<0.005),and from 0.54±0.19(0.27 LogMAR)pre-operatively to 0.62±0.19(0.21 LogMAR)post-operatively in the nomogram group(p<0.01),with statistically significant difference between the two groups(p<0.05),being better in the ANN group.Coma-like aberrations decreased significantly in the ANN group,while in the nomogram group they did not change significantly,but no statistically significant difference was found between the two groups.Conclusions:ANN to guide ICRS provides an increase in the visual acuity,reduction in the spherical equivalent and improvement in the optical quality of keratoconus patients.ANN gives better results when compared with the manufacturer’s nomo

关 键 词：KERATOCONUS Intracorneal ring segments Artificial intelligence Visual acuity Corneal aberrations 

分 类 号：R772.2[医药卫生—眼科]