iStent inject trabecular microbypass stent implantation with cataract extraction in open-angle glaucoma:early clinical experience  

作　　者：Tanner J.Ferguson Zachary Dockter Adam Bleeker Kayla L.Karpuk Justin Schweitzer Mitch J.Ibach John P.Berdahl 

机构地区：[1]Cole Eye Institute,Cleveland Clinic,Cleveland,OH,USA [2]University of South Dakota Sanford School of Medicine,Sioux Falls,SD,USA [3]Cleveland Eye Clinic,Cleveland,OH,USA [4]Vance Thompson Vision,Sioux Falls,SD,USA

出　　处：《Eye and Vision》2020年第1期266-274,共9页眼视光学杂志（英文）

基　　金：This study was funded by an investigator-initial trial grant from Glaukos Corp.(San Clemente,CA,USA).

摘　　要：Background:Retrospective,consecutive case series to evaluate the implantation of two second-generation trabecular microbypass stents in combination with cataract surgery in a real-world,clinical setting.Methods:The series included 56 eyes implanted with the iStent inject device with phacoemulsification.The series consisted of eyes with primary open-angle glaucoma(n=52)and pseudoexfoliative glaucoma(n=4).Primary outcome measures included intraocular pressure(IOP)and number of glaucoma medications.Safety outcomes included the need for secondary surgical intervention and the incidence of IOP spikes≥10 mmHg and≥15 mmHg.Results:IOP was reduced by 21%to 14.7±2.9 mmHg(p<0.01)at 6 months postoperative from 18.7±5.8 mmHg at baseline.Preoperatively,the mean number of glaucoma medications was 1.5±0.9 and reduced by 39%to 0.9±1.2(p<0.01)at 6 months.At 6 months,68%of eyes had an IOP≤15 mmHg,increased from 30%at baseline.55%of eyes were medication-free at 6 months,up from 18%at baseline.There were no severe postoperative complications.No eyes underwent an additional glaucoma procedure.Conclusions:Implantation of the iStent inject device with concomitant cataract surgery effectively provides a sustained reduction in IOP with a markedly improved medication burden out to 6 months postoperative.The safety profile is excellent.

关 键 词：Micro-invasive glaucoma surgery Minimally invasive glaucoma surgery MIGS Trabecular microbypass stent Open-angle glaucoma 

分 类 号：R779.66[医药卫生—眼科]