The associations of lens power with age,axial length and type 2 diabetes mellitus in Chinese adults aged 50 and above  

作　　者：Luyao Ye Jiangnan He Xinji Zhang Yi Xu Qiuying Chen Yao Yin Ying Fan Lina Lu Jianfeng Zhu Haidong Zou Xun Xu 

机构地区：[1]Department of Preventative Ophthalmology,Shanghai Eye Disease Prevention and Treatment Center,Shanghai Eye Hospital,No.380 Kangding Road,Shanghai 200040,China [2]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University,National Clinical Research Center for Eye Diseases,Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases,No.100 Haining Road,Shanghai 200080,China [3]Department of Health Statistics,Naval Military Medical University,No.800 Xiangyin Road,Shanghai 200433,China

出　　处：《Eye and Vision》2020年第1期563-570,共8页眼视光学杂志（英文）

基　　金：This study was funded by the National Natural Science Foundation of China(Grant No.:81670898 and 81703287,Beijing,China);the Shanghai Three-Year Public Health Action Program(Project Nos.GWIV-3.3 and GWIV-13.1,Shanghai,China);the Shanghai High-level Overseas Training Team Program on Eye Public Health(Project No.GWTD2015S08,Shanghai,China);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(Project No.20172022,Shanghai,China);Shanghai General Hospital,Clinical Research(Project No.CTCCR-2018Z01,Shanghai,China);the Shanghai Science and Technology Commission Research Project(Project No.17ZR1426900,Shanghai,China);the Shanghai Municipal Planning Commission of Science and Research Fund(Project No.201640090,Shanghai,China);National Key R&D Program of China(Project No.2016YFC0904800,2019YFC0840607);National Science and Technology Major Project of China(Project No.2017ZX09304010);The sponsors or funding organizations had no role in the design or conduct of this research.

摘　　要：Background:To investigate the associations of lens power with age,axial length(AL),and Type 2 diabetes mellitus(DM)in Chinese adults aged 50 and above.Methods:Random clustering sampling was used to identify adults aged 50 years and above in urban regions of Shanghai.The participants underwent a comprehensive ophthalmic examination including subjective refraction,autorefraction,and IOL-Master.The crystalline lens power was calculated using Bennett’s formula.Results:A total of 4177 adults were included.A linear decrease in lens power was observed both with age and with AL,followed by a stop of lens power loss after the age of 70 or when AL≥25 mm,respectively.Participants with Type 2 DM presented higher lens power(0.43 diopter(D),p<0.001)and thicker lens thickness(0.06 mm,p<0.001).In multivariate regression models,there was a positive correlation between lens power and Type 2 DM when age<75 years(p<0.001)or AL<25 mm(p<0.001)after adjusting for other factors,while no significant association was found in participants aged≥75 years(p=0.122)or with AL≥25 mm(p=0.172).Conclusions:The lens power in adults aged 50 and above exhibited two stages with age and with AL.Type 2 DM caused an increase in lens power,which was not seen in participants aged≥75 years or with AL≥25 mm.

关 键 词：Lens power Type 2 diabetes mellitus Chinese adults Cross-sectional study 

分 类 号：R77[医药卫生—眼科] R587.2[医药卫生—临床医学]