太原市学龄前儿童幽门螺杆菌感染及克拉霉素耐药状况调查  

Investigation of Helicobacter Pylori Infection and Kramycin Resistance in Preschool Children in Taiyuan City

作　　者：于慧[1] 张文清[1] 贺婧 张俊 张巧英 张丽[1] YU Hui;ZHANG Wen-qing;HE Jing;ZHANG Jun;ZHANG Qiao-ying;ZHANG Li(Taiyuan Center Hospital,Taiyuan,Shanxi,030001,China)

机构地区：[1]太原市中心医院消化内科,山西太原030001

出　　处：《中国血液流变学杂志》2021年第4期584-586,共3页Chinese Journal of Hemorheology

基　　金：山西省重点研发计划社会发展项目(201903D321030)。

摘　　要：目的了解太原市学龄前儿童的幽门螺杆菌感染(Helicobacter pylori,HP)状况,及其克拉霉素耐药率,为儿童HP感染预防提供依据。方法采用粪便核酸扩增的方法,抽查太原市南北两所幼儿园120名学龄前儿童,对其粪便标本进行Real time PCR扩增,并对阳性者克拉霉素耐药基因23S rDNA进行扩增。结果120名学龄儿童粪便标本共有22例HP阳性,阳性率为18.33%,其中有8例为克拉霉素耐药,耐药率为36.36%。结论太原市学龄前儿童HP感染率与全国持平,并且具有较高的克拉霉素耐药率。Objective To understand the status of Helicobacter pylori(HP)infection in preschool children in Taiyuan city,and its rate of Klamycin resistance,to provide a basis for the prevention of HP infection in children.Methods Real time PCR was used for amplification of 120 preschool children's fecal specimens in two kindergartens in the north and south of Taiyuan city,and then the drug-resistant gene 23S rDNA of Kramycin was amplified.Results A total of 22 positive fecal samples of 120 preschool-age children had positive amplification,the infection rate was 18.33%,of which 8 were Kramycin-resistant,the rate was 36.36%.Conclusion The infection rate of HP in preschool children in Taiyuan city is the same as that in the whole country,and has a high rate of Kramycin resistance.

关 键 词：学龄前儿童 幽门螺杆菌 克拉霉素 耐药 

分 类 号：R573.3[医药卫生—消化系统]