正常大小卵巢癌综合征的原发性浆液性癌临床病理特征及其预后影响因素  

Clinicopathological characteristics and prognostic factors of Normal sized Ovary Serous carcinoma

作　　者：王安娜 龙再秋 WANG An-na;LONG Zai-qiu(Department of Gynecology,Cancer Hospital of China Medical University,Liaoning Cancer Hospital and Institute,Shenyang 110042,China)

机构地区：[1]中国医科大学肿瘤医院辽宁省肿瘤医院妇科,辽宁沈阳110042

出　　处：《中国实用妇科与产科杂志》2022年第2期227-231,共5页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：中科院大连化物所-辽宁省肿瘤医院肿瘤质谱中心资助项目(ZP202006)。

摘　　要：目的探讨正常大小卵巢癌综合征的原发性卵巢浆液性癌临床病理特征及预后影响因素。方法回顾性分析2007年1月1日至2015年12月31日就诊于中国医科大学肿瘤医院的正常大小卵巢癌综合征的原发性卵巢浆液性癌81例患者为研究组,同期入院的原发性大卵巢癌149例患者为对照组,比较两组临床病理特征及预后影响因素。结果研究组占同期入院卵巢癌患者的7.2%。研究组与对照组比较,年龄(58岁vs.54岁,P=0.007),FIGOⅢ期、Ⅳ期占比(98.8%vs.85.9%,P=0.003),手术结果R0+R1占比(76.5%vs.57.7%,P=0.004),差异均存在统计学意义,残留部位前者更广泛,中位生存时间为40个月vs.47个月(P=0.007),无疾病进展生存时间为18个月vs.25个月(P<0.001),多因素Cox回归分析得出卵巢大小是影响无疾病进展生存期(PFS)和总生存期(OS)的独立危险因素,临床分期、术前CA125水平、初次肿瘤细胞减灭术后残余瘤大小是影响PFS的独立危险因素,多因素Cox回归亚组分析中得出卵巢大小是影响PFS和OS的独立危险因素。结论正常大小卵巢癌综合征的原发性卵巢浆液性癌发病率低,病变范围广泛,预后差。Objective To explore Clinicopathological characteristics and prognostic factors of Normal sized Ovary Serous carcinoma.Methods We retrospectively compared with Normal sized Ovary Serous carcinoma(experimental group)and enlarged ovarian cancer(control group)in Cancer Hospital of China Medical University between 2007 and2015.Results Experimental group accounted for 7.2% of all patients with ovarian cancer in our hospital between 2007 and 2015. The mean age of patients with experimental group was significantly higher than those control group(58 vs. 54 years). Furthermore,the group of patients with experimental group had a significantly higher proportion of FIGO Ⅲ andⅣ cases than the control group(98.8% vs. 85.9%;P=0.003). The ratio of surgery results for <R1 were 76.5% and57.7%,P=0.004. Residual areas were widely distributed. The median overall survival time(OS)for patients with experimental group and those with control group was 40 months and 47 months(P<0.001),while the progression-free survival(PFS)was 19 months and 26 months(P<0.001). Multivariate Cox regression analysis indicated that ovarian size was an independent risk factor for both PFS and OS,while FIGO,CA125 level and residual tumor size was an independent risk factor for PFS. Multivariate Cox regression subgroup analysis indicated that ovarian size was an independent risk factor for both PFS and OS.Conclusion Normal sized Ovary Serous carcinoma has a low incidence,a wide range of lesions,and a poor prognosis.

关 键 词：原发性卵巢上皮性癌 预后 正常大小卵巢癌综合征 临床病理特征 

分 类 号：R737.3[医药卫生—肿瘤]