CA125 ADA MCP-1检测对结核性胸腔积液与恶性胸腔积液的诊断价值  

The diagnostic value of CA125,ADA and MCP-1 in tuberculous pleural effusion and malignant pleural effusion

作　　者：张会强 文政芳[1] 张力公[1] 张冬杰[1] Zhang Huiqiang;Wen Zhengfang;Zhang Ligong;Zhang Dongjie(The First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,Henan,China)

机构地区：[1]新乡医学院第一附属医院,河南卫辉453100

出　　处：《临床心身疾病杂志》2022年第1期113-116,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨糖类抗原125、腺苷脱氨酶、单核细胞趋化蛋白1联合检测对结核性胸腔积液与恶性胸腔积液的诊断价值。方法将90例伴有胸腔积液的肺结核患者设为结核组,90例伴有胸腔积液的肺癌患者设为肺癌组,检测两组胸腔积液中糖类抗原125、腺苷脱氨酶、单核细胞趋化蛋白1水平,采用受试者工作特征曲线分析三者单独及联合检测对胸腔积液性质的诊断价值。结果肺癌组胸腔积液糖类抗原125水平显著高于结核组(P<0.01),腺苷脱氨酶、单核细胞趋化蛋白1水平显著低于结核组(P<0.01)。糖类抗原125鉴别诊断结核性胸腔积液与恶性胸腔积液的灵敏度为39.77%、特异度为72.61%、曲线下面积为0.630,腺苷脱氨酶的灵敏度为69.84%、特异度为84.26%、曲线下面积为0.750,单核细胞趋化蛋白1的灵敏度为58.32%、特异度为75.58%、曲线下面积为0.679,联合检测的灵敏度为92.76%、特异度为81.59%、曲线下面积为0.868。结论糖类抗原125在肺癌患者胸腔积液中水平明显上升,腺苷脱氨酶、单核细胞趋化蛋白1在肺结核患者胸腔积液中水平明显上升,糖类抗原125、腺苷脱氨酶、单核细胞趋化蛋白1联合诊断能够提高临床胸腔积液的诊断效能。Objective To investigate the diagnostic value of carcinoembryonic antigen 125(CA125),adenosine deaminase(ADA) and monocyte chemoattractant protein-1(MCP-1) in tuberculous pleural effusion and malignant pleural effusion.Methods Ninety cases of tuberculosis patients with pleural effusion were set as tuberculosis group and 90 cases of lung cancer patients with pleural effusion were set as lung cancer group.The levels of CA125,ADA and MCP-1 in pleural effusion of the two groups were detected.Receiver operating characteristic(ROC) was used to analyze the diagnostic value of the three alone and combined detection in the nature of pleural effusion.Results The level of CA125 in the pleural effusion of the lung cancer group was significantly higher than that of the tuberculosis group(P<0.01).The levels of ADA and MCP-1 in the pleural effusion of the lung cancer group were significantly lower than those of the tuberculosis group(P<0.01).The sensitivity,specificity and area under the curve of CA125 in the differential diagnosis of tuberculous pleural effusion and malignant pleural effusion were 39.77%,72.61 % and 0.630 respectively.The sensitivity,specificity and area under the curve of ADA were 69.84%,8 4.26% and 0.750 respectively.The sensitivity,specificity and area under the curve of MCP-1 were 5 8.32%,75.58%and 0.679 respectively.The sensitivity,specificity and area under the curve of the combined detection were 92.76%,81.59% and 0.868 respectively.Conclusions The level of CA125 in the pleural effusion of lung cancer patients increased significantly,and the levels of ADA and MCP-1 in the pleural effusion of tuberculosis patients increased significantly.The combined detection of CA125,ADA and MCP-1 can improve the diagnostic efficiency of clinical pleural effusion.

关 键 词：肺癌 肺结核 胸腔积液 糖类抗原125 腺苷脱氨酶 单核细胞趋化蛋白1 

分 类 号：R734.2[医药卫生—肿瘤] R521[医药卫生—临床医学]