偏头痛脑白质病变与卵圆孔未闭的Meta分析  

Meta-analysis of white matter lesions and patent foramen ovale in migraine

作　　者：胡洋 冯晓燕 马涛[1] HU Yang;FENG Xiao-yan;MA Tao(Department of Neurology,Wuxi Second People Hospital of Nanjing Medical University,Wuxi 214002,China)

机构地区：[1]南京医科大学无锡第二人民医院神经内科,214002

出　　处：《临床神经病学杂志》2022年第1期16-18,共3页Journal of Clinical Neurology

基　　金：无锡市“双百”中青年医疗卫生拔尖人才(BJ2020023);南京医科大学校级基金(NMUB20210302)。

摘　　要：目的探讨偏头痛脑白质病变(WML)与先天性卵圆孔未闭(PFO)的关系。方法检索万方数据库、中国知网、中国生物医学文献数据库、Pubmed、The Cochrane Library、Embase中截至2020年2月17日的WML与PFO关系的相关文献,用RevMan 5.3软件进行Meta分析。结果纳入5篇文献,包括645例偏头痛患者。偏头痛患者的PFO发生率为57.5%,WML的发生率为42.8%。PFO偏头痛和无PFO偏头痛患者的WML发生率差异无统计学意义(OR=1.31,95%CI:0.93~1.84,P=0.13)。结论偏头痛患者WML与PFO可能无关。Objective To investigate the correlation between white matter lesions(WML)and patent foramen ovale(PFO)in migraineurs.Methods Literatures on the relationship between WML and PFO were searched from Wanfang Database,CNKI,Chinese Biomedical Literature Database Medline,Pubmed,Cochrane and Embase.The deadline of the literature search was February 17,2020.RevMan 5.3 software was used for Meta-analysis.Results There were five articles included 645 migraineurs eventually identified.The detection rate of PFO in migraineurs was 57.5%,and the incidence of WML was 42.8%.There was no significant difference in the incidence of WML between migraine with PFO and migraine without PFO(OR=1.31,95%CI:0.93-1.84,P=0.13).Conclusion WML in migraine patients may not be related to PFO.

关 键 词：右向左分流 脑白质病变 偏头痛 先天性卵圆孔未闭 

分 类 号：R747.2[医药卫生—神经病学与精神病学]