3-氯-2,6-二硝基喹喔啉的合成工艺研究  

Synthesis of 3-chloro-2,6-dinitroquinoxaline

作　　者：高婷 周志旭[2] 苏静杰 刘家芳 谢国旺 柴慧芳 Gao Ting;Zhou Zhixu;Su Jingjie;Liu Jiafang;Xie Guowang;Chai Huifang(School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025;School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025 [2]贵州大学药学院,贵州贵阳550025

出　　处：《广东化工》2022年第6期18-20,共3页Guangdong Chemical Industry

基　　金：贵州中医药大学2018年度学术新苗培养及创新探索专项项目培育项目计划(黔科台平台人才[2018]5766号-14);贵州省科技计划项目:黔科合平台人才[2018]5781号。

摘　　要：喹喔啉为一类重要的苯并吡嗪类杂环化合物,喹喔啉衍生物在医药及化工合成领域具有重要的作用。3-氯-2,6-二硝基喹喔啉是一种重要医药化工中间体。本文以2-羟基喹喔啉为原料,经硝化反应和氯代反应两步反应得到目标化合物。该合成方法操作简便、后处理操作简便,花费时间少且产物纯度高、收率也较高,产品收率为58.2%,适合工业化生产。Quinoxaline is an important compound of benzopyrazine heterocycles. Quinoxaline derivatives play an important role in the field of medicine and chemical synthesis.3-chloro-2,6-dinitroquinoxaline is an important pharmaceutical and chemical intermediate. In this article, quinoxalin-2-ol was used as the starting material, and the target compound was obtained by two steps of nitrification and chlorination. The synthesis method is simple in operation, simple in post-treatment, taking less time in post-treatment and high in product purity and yield, and the product yield is 58.2 %, which is suitable for industrial production.

关 键 词：3-氯-2 6-二硝基喹喔啉 2-羟基喹喔啉 合成 工艺 医药 

分 类 号：TQ[化学工程]