4-丁脒基-3-甲基苯甲酸的合成研究  

Synthesis of 4-butyrimidamido-3-methylbenzoic Acid

作　　者：邹云豪 刘跃龙 Zou Yunhao;Liu Yuelong(School of Chemistry and Chemical Engineering,Jiangxi Science and Technology Normal University,Nanchang 330031;Jiangxi Engineering Laboratory of Waterborne Coating,Nanchang 330031,China)

机构地区：[1]江西科技师范大学化学化工学院,江西南昌330031 [2]江西省水性涂料工程实验室,江西南昌330031

出　　处：《广东化工》2022年第6期28-31,共4页Guangdong Chemical Industry

基　　金：国家自然科学基金资助项目(51564011)。

摘　　要：探究4-丁脒基-3-甲基苯甲酸的合成工艺。以正丁腈、甲醇、氯化氢气为起始原料,制备丁亚胺酸甲酯盐酸盐。碱化后,游离的丁亚胺酸甲酯与4-氨基-3-甲基苯甲酸反应得到4-丁脒基-3-甲基苯甲酸。研究了物料料比、反应温度、反应时间对产品收率的影响。4-丁脒基-3-甲基苯甲酸收率达85%以上(以4-氨基-3-甲基苯甲酸计算),纯度在99%以上。To investigate the synthesis process of 4-butyrimidamido-3-methylbenzoic acid. n-Butylimide ester hydrochloride was prepared using n-butyronitrile, methanol and hydrogen chloride as starting materials. After alkalinization, the free n-butylimide ester reacts with 4-amino-3-methylbenzoic acid to give 4-butyrimidamido-3-methylbenzoic acid. The effects of material to material ratio, reaction temperature and reaction time on the product yield were investigated. More than 85 % yield of 4-butyrimidamido-3-methylbenzoic acid(calculated as 4-amino-3-methylbenzoic acid). The purity is above 99 %.

关 键 词：4-丁脒基-3-甲基苯甲酸 替米沙坦 关键中间体 pinner反应 合成工艺 

分 类 号：TQ[化学工程]