Axin2阳性细胞在牙周组织发育与再生中的作用  

The role of Axin2^(+) cells in periodontal tissue development and regeneration

作　　者：时彬冕 谢旭东[1] 王骏 SHI Binmian;XIE Xudong;WANG Jun(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Periodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科,四川成都610041

出　　处：《口腔疾病防治》2022年第6期433-437,共5页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(82071127,81700980)。

摘　　要：WNT信号通路作为进化中高度保守的信号通路,在牙周组织生长发育和损伤修复中发挥重要调控作用。Axin相关蛋白Axin2作为WNT信号通路的直接效应分子,可对WNT效应细胞进行良好标记。研究显示,牙周组织内Axin2阳性(Axin2^(+))细胞具有自我更新、复制及多向分化潜能。本文对Axin2^(+)细胞在牙周组织发育过程中的时空分布,以及Axin2^(+)细胞在牙周组织发育、再生和组织改建中的作用及其调控机制研究进展作一综述,以期为牙周组织再生提供新的思路。现有研究表明,Axin2^(+)细胞是牙周组织发育的重要干细胞来源,Axin2^(+)细胞在拔牙窝愈合、种植体骨整合、牙周组织改建和结合上皮再生中均发挥重要作用。Axin2^(+)细胞的功能受到经典WNT信号通路的正向调控。然而,其他信号通路对Axin2^(+)细胞的调控机制仍有待阐明。As a highly conserved signal pathway in evolution, the WNT signaling pathway plays an essential role in periodontium growth, development and injury repair. The Axin-associated protein Axin2 is a direct effector molecule of the WNT signaling pathway and labels WNT-responsive cells well. Studies have shown that Axin2-positive(Axin2^(+))cells in the periodontium have the potential for self-renewal, replication and multidirectional differentiation. This article reviews the temporal and spatial distribution of Axin2^(+)cells in periodontal tissue development and the role and regulatory mechanism of Axin2^(+)cells in periodontal tissue development, regeneration and tissue remodeling to provide new ideas for periodontal tissue regeneration. The literature review showed that Axin2^(+)cells were the main cell source of periodontium development, and Axin2^(+)cells played essential roles in tooth extraction socket healing, implant osseointegration, periodontal tissue remodeling and junctional epithelium regeneration. The function of Axin2^(+)cells was positively regulated by the canonical WNT signaling pathway. However, the regulatory mechanisms of other signaling pathways on Axin2^(+)cells remain to be elucidated.

关 键 词：WNT信号通路 Axin2 牙周组织 发育 再生 干细胞 稳态 细胞谱系示踪 

分 类 号：R78[医药卫生—口腔医学]