伴有惊恐障碍的阻塞性睡眠呼吸暂停低通气综合征睡眠结构特征  

Structural features of sleep in patients with obstructive sleep apnea hypoventilation syndrome combined with panic disorder

作　　者：杨帅 孔晓艺 厉雪艳 柯道正[2] 胡孝朋[3] 葛义俊[1] YANG Shuai;KONG Xiaoyi;LI Xueyan;KE Daozheng;HU Xiaopeng;GE Yijun(The Affiliated Chaohu Hospital of Anhui Medical University,Chaohu 238000,China)

机构地区：[1]安徽医科大学附属巢湖医院睡眠障碍科,巢湖238000 [2]安徽医科大学第一附属医院干部心内科 [3]安徽医科大学第一附属医院放射科

出　　处：《中国神经精神疾病杂志》2021年第12期716-721,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：安徽高校自然科学研究项目(编号:KJ2018A0843);安徽医科大学校科研基金(编号:2020xkj053);载人航天工程航天医学实验领域项目(编号:HYZHXM03004)。

摘　　要：目的分析阻塞性睡眠呼吸暂停低通气综合征合并惊恐障碍(obstructive sleep apnea syndrome com⁃bined with panic disorder,OCP)患者的睡眠结构特征,探讨OCP睡眠结构变化在临床上的意义。方法纳入25例OCP患者、29例阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea syndrome,OSAS)患者和27名正常对照。使用焦虑自评量表(self-rating anxiety scale,SAS)、抑郁自评量表(self-rating depression scale,SDS)和匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)以评估被试情绪及睡眠质量,使用多导睡眠监测(polysomnography,PSG)评估睡眠结构特征。结果OCP患者的SAS、SDS、PSQI量表得分高于OSAS组和对照组(P<0.05)。OCP患者相较OSAS组和对照组,非快速动眼睡眠期1期百分比较高、睡眠潜伏期较长(P<0.05),快动眼睡眠期和非快速动眼睡眠期2期百分比较低(P<0.05)。OCP患者相较OSAS组快动眼睡眠期呼吸相关微觉醒指数、睡眠呼吸紊乱指数、低于90%血氧饱和度时间较低(P<0.05),最低血氧饱和度较高(P<0.05),但均差于对照组(P<0.05)。结论OCP患者相较于OSAS患者主客观睡眠质量更差,睡眠呼吸暂停程度较轻。Objective To investigate the sleep structure in patients with obstructive sleep apnea hypopnea syndrome combined panic disorder(OCP),and analyze its significance in the clinic.Methods Twenty-five patients with OCP,29 patients with obstructive sleep apnea syndrome(OSAS),and 27 healthy controls were included.Polysomnography(PSG),self-rating anxiety scale(SAS),self-rating depression scale(SDS)and Pittsburgh sleep quality index(PSQI)were used to evaluate the mood and sleep structure characteristics of patients.Results OCP group had higher SAS,SDS and PSQI scores compared to either OSAS group or control group(P<0.05).OCP group had higher percentage of non-REM 1 and sleep latency(P<0.05)and lower percentage of non-REM 2 and REM compared to either OSAS group or control group(P<0.05).OCP group had lower REM compared to the OSAS group(P<0.05).The respiratory-related microarousal index,sleep disordered breathing index,time below 90%oxygen saturation were lower(P<0.05)and the lowest oxygen saturation was higher in OCP group compared to OSAS group(P<0.05).However,all those three parameters were worse compared to the control group(P<0.05).Conclusion OCP patients have worse subjective and objective sleep quality and less sleep apnea compared to OSAS patients.

关 键 词：阻塞性睡眠呼吸暂停 低通气综合征 惊恐障碍 多导睡眠监测技术 睡眠质量 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R766[医药卫生—临床医学]