经腹与经胸贲门癌根治术治疗贲门癌患者的效果及对免疫功能的影响  

Effect of Transabdominal and Transthoracic Radical Resection of Cardiac Cancer and Its Influence on Immune Function

作　　者：李爱华[1] 闫元[1] 龚云翔 LI Aihua;YAN Yuan;GONG Yunxiang(Songzi People’s Hospital,Songzi 434200,China;不详)

机构地区：[1]松滋市人民医院,湖北松滋434200

出　　处：《中外医学研究》2022年第6期37-40,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究经腹和经胸贲门癌根治术治疗贲门的效果及对免疫功能的影响。方法:选取2017年4月-2018年4月松滋市人民医院收治的90例贲门癌患者,依据随机数字表法将患者分为经腹组和经胸组,每组45例。经胸组行经胸贲门癌根治术治疗,经腹组行经腹贲门癌根治术治疗。比较两组疗效、T细胞亚群(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))及生存率。结果:经腹组总有效率为97.78%,高于经胸组的80.00%,差异有统计学意义(P<0.05)。术后,经腹组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于经胸组,差异均有统计学意义(P<0.05)。经腹组并发症发生率为4.44%,低于经胸组的20.00%,差异有统计学意义(P<0.05)。两组患者的1年生存率、2年生存率比较,差异均无统计学意义(P>0.05)。经腹组患者的3年生存率高于经胸组,差异有统计学意义(P<0.05)。结论:经腹贲门癌根治术治疗贲门癌效果确切,该术机体创伤小,对免疫功能的影响较小,并发症少,可提高3年生存率,安全有效。Objective:To explore the curative effect of transabdominal and transthoracic radical resection of cardiac cancer and its influence on immune function.Method:A total of 90 patients with cardiac cancer admitted to Songzi People’s Hospital from April 2017 to April 2018 were selected,they were divided into the transabdominal group and the transthoracic group according to random number table method,with 45 cases in each group.The transthoracic group was treated with transthoracic radical resection of cardiac cancer,and the transabdominal group was treated with transabdominal radical resection of cardiac cancer.The efficacy,T cell subsets(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))and survival rate were compared between two groups.Result:The total effective rate of transabdominal group was 97.78%,which was higher than 80.00% of transthoracic group,the difference was statistically significant(P<0.05).After operation,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in transabdominal group were higher than those in transthoracic group,the differences were statistically significant(P<0.05).The complication rate of transabdominal group was 4.44%,which was lower than 20.00% of transthoracic group,the difference was statistically significant(P<0.05).There were no significant differences in 1-year survival rate and 2-year survival rate between two groups(P>0.05).The 3-year survival rate in the transabdominal group was higher than that in the transthoracic group,the difference was statistically significant(P<0.05).Conclusion:Transabdominal radical operation for cardiac cancer is effective,with less trauma,less influence on immune function and fewer complications,which can improve the 3-year survival rate,which is safe and effective.

关 键 词：经腹贲门癌根治术 经胸贲门癌根治术 贲门癌 

分 类 号：R735.2[医药卫生—肿瘤]