2015年至2019年山西地区非小细胞肺癌流行病学特征及预后影响因素分析  

Epidemiological characteristics and prognostic affecting factors analysis of non⁃small cell lung cancer from 2015 to 2019 in Shanxi

作　　者：杜欢[1] 童亚兰[2] 王敏 Du Huan;Tong Yalan;Wang Min(Department of Epidemiology,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China;Department of Medical Record,Shanxi Provincial Cancer Hospital,Taiyuan 030013,China)

机构地区：[1]山西省肿瘤医院流行病学研究室,太原030013 [2]山西省肿瘤医院病案室,太原030013

出　　处：《肿瘤研究与临床》2022年第1期47-50,共4页Cancer Research and Clinic

摘　　要：目的探讨2015年至2019年山西地区非小细胞肺癌(NSCLC)流行病学特征及预后影响因素。方法选择2015年1月至2019年12月山西省肿瘤医院17082例NSCLC患者作为研究对象,检索所有患者病历资料,分析患者年龄、性别、职业及吸烟史的流行病学特点。所有患者均给予常规治疗并进行18个月随访,根据随访结果分为死亡组(4391例)和生存组(12691例),对患者预后的影响因素进行单因素及多因素logistic回归分析。结果17082例NSCLC患者中,2015年为3058例(17.91%),2016年为3129例(18.32%),2017年为3325例(19.46%),2018年为3564例(20.86%),2019年为4006例(23.45%),不同年份确诊人数呈上升趋势(χ^(2)=21.593,P<0.05)。男性发病率略高于女性[51.76%(8841/17082)比48.24%(8241/17082)],64.12%(10953/17082)患者发生在61~80岁人群,且职业分布以工人[34.08%(5821/17082)]和农民[30.00%(5124/17082)]为主,56.69%(9683/17082)的患者具有吸烟史。多因素logistic回归分析结果表明,淋巴结转移、肿瘤分期Ⅲ~Ⅳ期、表皮生长因子受体敏感突变、初始胸腔积液是NSCLC患者预后不良的独立影响因素(均P<0.05)。结论山西地区2015年至2019年NSCLC发生率呈上升趋势,该病发生与性别、年龄及职业有关;预后影响因素较多,采取针对性干预措施有助于改善患者预后。Objective To investigate the epidemiological characteristics and prognostic affecting factors of non‑small cell lung cancer(NSCLC)in Shanxi from 2015 to 2019.Methods A total of 17082 patients with NSCLC in Shanxi Provincial Cancer Hospital from January 2015 to December 2019 were selected as the research subjects.The medical records of all patients were retrieved,and the epidemiological characteristics of the patients′age,gender,occupation and smoking history were analyzed.All patients were given conventional treatment and followed up for 18 months.According to the follow‑up results,they were divided into the death group(4391 cases)and the survival group(12691 cases).The single factor and multivariate logistic regression analysis was used to analyze the factors affecting the prognosis of patients.Results Among 17082 patients with NSCLC,there were 3058 cases(17.91%)in 2015,3129 cases(18.32%)in 2016,3325 cases(19.46%)in 2017,3564 cases(20.86%)in 2018,and 4006 cases(23.45%)in 2019,and the number of confirmed cases in different years showed an upward trend(χ^(2)=21.593,P<0.05).The incidence rate of males was slightly higher than that of females[51.76%(8841/17082)vs.48.24%(8241/17082)],64.12%(10953/17082)occurred in the 61-80 years old population,and the occupational distribution was predominantly workers[34.08%(5821/17082)]and farmers[30.00%(5124/17082)];there were 56.69%(9683/17082)patients with a history of smoking.Multivariate logistic regression analysis showed that lymph node metastasis,tumor stagingⅢ-Ⅳ,sensitive mutations of epidermal growth factor receptor,and initial pleural effusion were independent factors influencing the poor prognosis of patients with NSCLC(all P<0.05).Conclusions The incidence of NSCLC in Shanxi from 2015 to 2019 is on the rise.The incidence of this disease is related to gender,age and occupation.There are many factors affecting the prognosis of patients,and targeted interventions can help improve the prognosis.

关 键 词：癌 非小细胞肺 流行病学 调查分析 预后 

分 类 号：R734.2[医药卫生—肿瘤]