家族史与乳腺浸润性导管癌临床病理学特征的关系研究  

Association between family history and clinicopathological features in invasive ductal carcinoma of breast

作　　者：杨自国 汪洪斌 朱强[1] 曲更宝[1] 张铁[1] 王丕琳[1] Yang Ziguo;Wang Hongbin;Zhu Qiang;Qu Gengbao;Zhang Tie;Wang Pilin(Department of Breast Surgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;Department of Ultrasound,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京天坛医院乳腺科,北京100050 [2]首都医科大学附属北京天坛医院超声科,北京100050

出　　处：《中国医刊》2022年第4期396-398,共3页Chinese Journal of Medicine

摘　　要：目的探讨乳腺癌和/或卵巢癌(breast and/or ovarian cancer,BCOC)家族史与乳腺浸润性导管癌临床病理学特征的关系。方法纳入2019年1月至2020年12月首都医科大学附属北京天坛医院收治的237例女性乳腺浸润性导管癌患者,分析BCOC家族史与其他临床病理参数的关系。结果在237例患者中,76例(32.1%)有肿瘤家族史,其中32例(13.5%)有BCOC家族史。患者年龄越小,有BCOC家族史的比例越高(P=0.039)。有BCOC家族史的患者发病年龄[(47.1±9.2)岁]低于无家族史者[(52.6±9.5)岁],三阴性乳腺癌的比例(21.9%)高于无家族史者(9.8%),差异有显著性(P<0.05),但BCOC家族史与乳腺癌患者的肿瘤大小、组织学分级、TNM分期、腋窝淋巴结转移、ER、PR、HER2、是否双侧乳腺癌无关(P>0.05)。结论BCOC家族史与乳腺癌的发生密切相关,密切关注有家族史的女性可为乳腺癌的筛查、早期诊断和治疗提供有力的理论支持。Objective To analyze the the association between family history and clinicopathological characteristics in invasive ductal carcinoma of breast.Method Two hundred and thirty seven patient diagnosed as invasive ductal breast cancer patients diagnosed in the department of breast disease,Beijing Tiantan Hospital,Capital Medical University from January 2019 to December 2020 were involved in our study,and the association between family history of breast and/or ovarian cancer(BCOC)and clinical characteristics.Result Of the 237 patients,76(32.1%)had a family history of any cancer,and 32(13.5%)had a family history of BCOC.The younger the patients were,the higher the proportion of patients with family history of BCOC(P=0.039).Patient with BCOC family history are diagnosed as invasive ductal breast cancer at younger age[(47.1±9.2)years vs.(52.6±9.5)years,P<0.05]and have a higher percentage of triple negative breast cancer than the patients without family history(21.9%vs.9.8%,P=0.045).However,no association between family history and tumor size,grade,stage,lymph node metastasis,estrogen receptor(ER),progesterone receptor(PR)and human epidermal factor receptor-2(HER-2)status,and bilateral breast cancer(P>0.05).Conclusion Family history of BCOC play a pivotal role in invasive ductal breast cancer,and emphasizing on family history can provide theoretical support for breast cancer screening,early diagnosis,and treatment.

关 键 词：乳腺浸润性导管癌 家族史 发病年龄 三阴性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]