Synthesis of Axially Chiral Anilides Enabled by a Palladium/Ming-Phos-Catalyzed Desymmetric Sonogashira Reaction  

作　　者：Bin Yang Junfeng Yang Junliang Zhang 

机构地区：[1]Deportment of Chemistry,Fudon University,2005 Songhu Road,Shanghai 200438,China

出　　处：《Chinese Journal of Chemistry》2022年第3期317-322,共6页中国化学（英文版）

基　　金：the funding support of NSFC(Nos.22031004,21921003,21901043);Shanghai Municipal Education Commission(No.20212308).

摘　　要：Atropisomeric anilides are one of important C-N axially chiral compounds.Compared with the A/-terminal functionalization to prepare such compounds,C-terminal functionalization strategies have been rarely reported.We describe herein an efficient synthesis of axially chiral anilides enabled by Pd-catalyzed desymmetric Sonogashira cross-coupling reactions with the use of a newly identified Ming-Phos.Moderate to high yields with high enantioselectivities(up to 98%ee)were obtained.

关 键 词：ATROPISOMERISM Axially chiral anilides SadPhos DESYMMETRIZATION Sonogashira cross-coupling Kinetic resolution 

分 类 号：O62[理学—有机化学]