Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon  

作　　者：Wen-Fang Yi Tiwalade A.Adelakun Xue Bai Yu Zhang Xiao-Jiang Hao 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan 650201,China

出　　处：《Chinese Journal of Chemistry》2022年第4期475-479,共5页中国化学（英文版）

基　　金：supported financially by grants from NSFC(81874295);Top Young Talent of the Ten Thousand Talents Program of Yunnan(to Y.Zhang).

摘　　要：Comprehensive Summary Tabernaesine J(1),an unprecedented vincamine-type indole alkaloid with 6/5/6/6/6/5/5 heptacyclic-ring system,as well as one new biogenetically related vincamine-type indole alkaloid(2),were isolated from leaves of Tabernaemontana pachysiphon.Their structures were established by a combination of HRESIMS,NMR,single crystal X-ray diffraction,and ECD calculation.The unprecedented pen-ta-lactone ring in tabernaesine J(1)was postulated to be derived from acetyl-CoA enolate anion.Alkaloid 2 combined with fluconazole has the potential to overcome fluconazole resistance in Candida albicans.

关 键 词：Natural products ALKALOIDS Structure elucidation Tabernaemontana pachysiphon Tabernaesine J 

分 类 号：O62[理学—有机化学]