新疆维吾尔自治区乌鲁木齐市一起肉毒中毒事件调查分析  

An investigation of a botulism poisoning event in Urumqi,Xinjiang

作　　者：古丽娜·吐尔地[1] 高鹏亚 孙晖[3] 孙喜贺 李鑫悦 卢选成[5] 刘洋[4] 徐雪芳[3] Gulina Tuerdi;Gao Pengya;Sun Hui;Sun Xihe;Li Xinyue;Lu Xuancheng;Liu Yang;Xu Xuefang(Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention,Urumqi 830002,Xinjiang,China;College of Animal Husbandry and Veterinary Medicine,Shenyang Agricultural University,Shenyang 110866,Liaoning,China;State Key Laboratory of Communicable Disease Prevention and Control,Institute for Communicable Disease Prevention and Control,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of Food Science,College of Biochemical Engineering,Beijing Union University,Beijing 100023,China;Laboratory Animal Center,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]新疆维吾尔自治区疾病预防控制中心,新疆乌鲁木齐830002 [2]沈阳农业大学畜牧兽医学院,辽宁沈阳110866 [3]中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室,北京102206 [4]北京联合大学生物化学工程学院食品科学系,北京100023 [5]中国疾病预防控制中心实验动物中心,北京102206

出　　处：《疾病监测》2022年第1期45-49,共5页Disease Surveillance

基　　金：国家重点研发计划(No.2018YFC1603800);启明星基金(No.202011417SJ142)。

摘　　要：目的通过对新疆维吾尔自治区乌鲁木齐市一起肉毒中毒事件进行调查分析和实验室检测,并采取有效措施预防。方法通过查阅就诊记录、访谈相关医生并通过入户调查方式进行现场流行病学调查,采集病例粪便、剩余食物等进行肉毒毒素实验室检测及分型鉴定。结果确诊病例2例,均被收治入院。使用A、B型肉毒抗毒素治疗后,症状明显缓解。实验室分离到肉毒梭菌,经荧光定量PCR方法检测携带A型毒素基因,确定为A型肉毒梭菌,小鼠实验检测到A型肉毒毒素。结论本次事件是一起由家庭自制豆豉引起的肉毒梭菌中毒,由A型肉毒梭菌污染导致,建议加强居民教育,防止食品制作和储存环节污染。Objective To investigate the pathogenic factors and causes of a botulism poisoning event and provide evidence for the prevention and control of the similar events in the future.Methods Field epidemiological survey was conducted through consulting medical records,interviewing relevant doctors and household survey.Laboratory test was done after collecting case stool samples and residual food samples for the detection of Clostridium botulinum.Results Two poisoning cases were confirmed and admitted to hospital.After botulinum antitoxin A and B treatment,the symptoms were significantly alleviated.C.botulinum was isolated,which was identified as type A C.botulinum after detection of type A toxin gene by real time quantitative PCR.Type A botulinum toxin was detected in mouse experiments.Conclusion This poisoning event was caused by homemade tempeh contaminated by C.botulinum type A.It is recommended to strengthen health education about the prevention of contamination in food production and storage.Medical institutions should prepare emergency medicines for food poisoning.Antitoxin serum should be used for the treatment of botulism poisoning.

关 键 词：肉毒中毒 肉毒梭菌 家庭自制 新疆维吾尔自治区 

分 类 号：R211[医药卫生—中医学] R378.8