^(18)F-FDG PET/CT检测淋巴结转移性鳞癌原发灶的价值  

The value of ^(18)F-FDG PET/CT imaging in detecting the primary foci of lymph node metastatic squamous cell carcinoma

作　　者：张冬萍 李莹 刘雨琪 周智洋 Zhang Dongping;Li Ying;Liu Yuqi;Zhou Zhiyang(Department of Diagnostic Radiology,Foresea Life Insurance Guangzhou General Hospital,Guangzhou 511300,China;PET/CT Center,the Central Hospital of Chancheng District of Foshan City in Guangdong Province,Foshan 528000,China)

机构地区：[1]前海人寿广州总医院放射诊断科,511300 [2]广东省佛山市禅城区中心医院PET/CT中心,528000

出　　处：《国际放射医学核医学杂志》2021年第9期570-575,共6页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的探讨^(18)F-氟脱氧葡萄糖(FDG)PET/CT在淋巴结转移性鳞癌原发灶检测中的临床应用价值。方法选取2018年3月至2020年11月于广东省佛山市禅城区中心医院因发现淋巴结转移性鳞癌而原发灶不明行全身^(18)F-FDG PET/CT检查的56例患者进行回顾性研究,其中男性44例、女性12例,年龄19~81岁,中位年龄51岁。所有患者的淋巴结转移性鳞癌均于^(18)F-FDG PET/CT显像前经组织病理学检查确诊,原发灶经组织病理学检查或临床随访确诊。分析并计算^(18)F-FDG PET/CT检测原发灶的检出率;原发灶与淋巴结转移部位、最大标准化摄取值(SUV_(max))的关系。采用双变量相关分析法分析原发灶与淋巴结转移灶的SUV_(max)的相关性。结果56例患者中,^(18)F-FDG PET/CT检测原发灶阳性44例(真阳性42例、假阳性2例),检出率为75.0%;假阴性1例(鼻咽癌);11例患者^(18)F-FDG PET/CT未发现原发灶。双变量相关分析结果显示,原发灶与淋巴结转移灶的SUV_(max)在一定程度上具有一致性(r=0.320,P<0.05)。结论^(18)F-FDG PET/CT显像对淋巴结转移性鳞癌的不明原发灶检测具有较好的临床应用价值,淋巴结转移灶与原发灶的^(18)F-FDG代谢强度存在良好的相关性。Objective To investigate the clinical value of ^(18)F-FDG PET/CT imaging in detecting primary foci by analyzing images of squamous carcinoma patients with lymph node metastatic.Methods A retrospective analysis was performed on 56 patients(44 males and 12 females,aged 19−81,with a median age of 51),who underwent whole-body ^(18)F-FDG PET/CT for the diagnosis of metastatic squamous carcinoma with unknown primary foci during March 2018 to November 2020 at the Central Hospital of Chancheng District of Foshan City in Guangdong Province.Prior to imaging,the diagnosis of metastatic squamous cell carcinoma was confirmed by pathological examination in all patients,and the primary foci were confirmed by pathological examination or clinical follow-up.To analyze and calculate the detection rate of ^(18)F-FDG PET/CT in the diagnosis of primary lesion and the relationship between primary lesion and lymph node metastasis and maximum standardized uptake value(SUV_(max)).SUV_(max) of primary tumor and lymph node metastasis were analyzed by bivariable correlation analysis.Results Among 56 patients,44 positive cases(42 true positive cases and 2 false positive cases)were detected by ^(18)F-FDG PET/CT,with a detection rate of 75.0%and 1 false negative(nasopharyngeal carcinoma).Primary foci in 11 patients remained unfound by ^(18)F-FDG PET/CT.The SUV_(max) of primary and metastatic foci were consistent to some extent(r=0.320,P<0.05).Conclusion ^(18)F-FDG PET/CT imaging has good clinical value for the detection of unspecified primary foci in metastatic squamous cell carcinoma,and there is a good correlation between the intensity of glucose metabolism in the primary foci and metastatic foci.

关 键 词：肿瘤 未知原发灶 淋巴结转移 癌 鳞状细胞 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术 X线计算机 最大标准化摄取值 

分 类 号：R733.4[医药卫生—肿瘤] R730.44[医药卫生—临床医学]